-transparent.png){kind=logo}
The effects of phorbol esters and diacylglycerol on phosphate accumulation in the cultured mouse kidney cells were investigated to assess the possible role of Ca2+-activated, phospholipid dependent protein kinase (protein kinase C) on the renal phosphate handling. 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulated phosphate accumulation dose-dependently. TPA-induced phosphate accumulation was synergistically enhanced with A23187. 4 alpha-phorbol 12,13-didecanoate did not stimulate the phosphate accumulation, while 4 beta-phorbol 12,13-didecanoate stimulated it. Additionally, 1-oleoyl-2-acetyl-glycerol exhibited a stimulatory effect on phosphate accumulation. These data indicated that protein kinase C is one of possible regulators of phosphate transport at the renal tubules.
Y Kinoshita, and
M Fukase, and
T Yamatani, and
R Hishikawa, and
T Fujita
May 1986,
The American journal of physiology,
Y Kinoshita, and
M Fukase, and
T Yamatani, and
R Hishikawa, and
T Fujita
April 1985,
Endocrinology,
Y Kinoshita, and
M Fukase, and
T Yamatani, and
R Hishikawa, and
T Fujita
January 1988,
The American journal of physiology,
Y Kinoshita, and
M Fukase, and
T Yamatani, and
R Hishikawa, and
T Fujita
August 1985,
The American journal of physiology,
Y Kinoshita, and
M Fukase, and
T Yamatani, and
R Hishikawa, and
T Fujita
January 1982,
Carcinogenesis; a comprehensive survey,
Y Kinoshita, and
M Fukase, and
T Yamatani, and
R Hishikawa, and
T Fujita
December 1990,
Biochemical and biophysical research communications,
Y Kinoshita, and
M Fukase, and
T Yamatani, and
R Hishikawa, and
T Fujita
August 1992,
Endocrinology,
Y Kinoshita, and
M Fukase, and
T Yamatani, and
R Hishikawa, and
T Fujita
September 1995,
The Journal of biological chemistry,
Y Kinoshita, and
M Fukase, and
T Yamatani, and
R Hishikawa, and
T Fujita
April 1987,
The American journal of physiology,
Y Kinoshita, and
M Fukase, and
T Yamatani, and
R Hishikawa, and
T Fujita
July 1983,
Endocrinology,
