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A 57-year-old male patient with metastasizing non-beta islet cell carcinoma of the pancreas is described. Both gastrin and VIP levels were elevated and the patient suffered from a syndrome of pancreatic cholera and hyperacidity. The tumour contained gastrin and VIP as demonstrated by immunofluorescence. The patient also had a history of familial renal stone formation and parathyroid nodular hyperplasia. Resection of pancreatic tumour in 1973 resulted in four years without symptoms. In 1977 definite signs of multiple hepatic metastases appeared. These signs disappeared after streptozotocin given in a dosage of 2 g three times at weekly intervals. The patient had remained well for 20 months after this treatment. The causative agents for the clinical syndrome in this case are discussed in view of circulating hormone levels.
K Oberg, and
H Boström, and
J Fahrenkrug, and
J F Dymling, and
O B Shaffalitsky de Muckadell, and
G Lundqvist
June 1976,
Deutsche medizinische Wochenschrift (1946),
K Oberg, and
H Boström, and
J Fahrenkrug, and
J F Dymling, and
O B Shaffalitsky de Muckadell, and
G Lundqvist
January 1982,
Digestion,
K Oberg, and
H Boström, and
J Fahrenkrug, and
J F Dymling, and
O B Shaffalitsky de Muckadell, and
G Lundqvist
January 1976,
Clinical endocrinology,
K Oberg, and
H Boström, and
J Fahrenkrug, and
J F Dymling, and
O B Shaffalitsky de Muckadell, and
G Lundqvist
January 1979,
Scandinavian journal of gastroenterology. Supplement,
K Oberg, and
H Boström, and
J Fahrenkrug, and
J F Dymling, and
O B Shaffalitsky de Muckadell, and
G Lundqvist
November 1975,
Klinicheskaia meditsina,
K Oberg, and
H Boström, and
J Fahrenkrug, and
J F Dymling, and
O B Shaffalitsky de Muckadell, and
G Lundqvist
May 1975,
Wiadomosci lekarskie (Warsaw, Poland : 1960),
K Oberg, and
H Boström, and
J Fahrenkrug, and
J F Dymling, and
O B Shaffalitsky de Muckadell, and
G Lundqvist
October 1981,
Ugeskrift for laeger,
K Oberg, and
H Boström, and
J Fahrenkrug, and
J F Dymling, and
O B Shaffalitsky de Muckadell, and
G Lundqvist
May 1975,
Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen,
K Oberg, and
H Boström, and
J Fahrenkrug, and
J F Dymling, and
O B Shaffalitsky de Muckadell, and
G Lundqvist
April 1979,
La Nouvelle presse medicale,
K Oberg, and
H Boström, and
J Fahrenkrug, and
J F Dymling, and
O B Shaffalitsky de Muckadell, and
G Lundqvist
June 1977,
L'union medicale du Canada,
