[Indium-111 antimyosin monoclonal antibody uptake in patients with cardiomyopathy and myocarditis]. 1990

A Matsumori, and T Yamada, and S Morishima, and N Tamaki, and Y Watanabe, and Y Yonekura, and K Endo, and J Konishi, and A Yoshida, and C Kawai
Department of Internal Medicine, Kyoto University Faculty of Medicine.

Prognostic significance of myocardial uptake of indium-111 antimyosin antibody was evaluated in 17 patients with idiopathic cardiomyopathy; 10 patients with dilated cardiomyopathy and 7 patients with hypertrophic cardiomyopathy. Seven of 10 patients with dilated cardiomyopathy showed positive images. Three of these 7 patients with strongly positive scans died after scintigraphic examination. Six of 7 patients with hypertrophic cardiomyopathy showed positive images. Three of the patients with dilated left ventricle had prominent positive scans and higher heart to lung ratio. The heart to lung ratio of antimyosin uptake in total patients was correlated with left ventricular end-diastolic dimension and ejection fraction measured by echocardiography. In patients with myocarditis, all three patients showed positive scintigrams within 4 weeks after the onset of the disease and 1 of 6 patients was positive thereafter, who had dilated ventricle and decreased cardiac function. Thus, indium-111 antimyosin antibody imaging may be useful to evaluate prognosis of patients with cardiomyopathy and myocarditis.

UI MeSH Term Description Entries
D007205 Indium Radioisotopes Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes. Radioisotopes, Indium
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009202 Cardiomyopathies A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS). Myocardial Disease,Myocardial Diseases,Myocardial Diseases, Primary,Myocardial Diseases, Secondary,Myocardiopathies,Primary Myocardial Disease,Cardiomyopathies, Primary,Cardiomyopathies, Secondary,Primary Myocardial Diseases,Secondary Myocardial Diseases,Cardiomyopathy,Cardiomyopathy, Primary,Cardiomyopathy, Secondary,Disease, Myocardial,Disease, Primary Myocardial,Disease, Secondary Myocardial,Diseases, Myocardial,Diseases, Primary Myocardial,Diseases, Secondary Myocardial,Myocardial Disease, Primary,Myocardial Disease, Secondary,Myocardiopathy,Primary Cardiomyopathies,Primary Cardiomyopathy,Secondary Cardiomyopathies,Secondary Cardiomyopathy,Secondary Myocardial Disease
D009205 Myocarditis Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies. Carditis,Myocarditides
D009206 Myocardium The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow. Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D009218 Myosins A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain. Myosin ATPase,ATPase, Actin-Activated,ATPase, Actomyosin,ATPase, Myosin,Actin-Activated ATPase,Actomyosin ATPase,Actomyosin Adenosinetriphosphatase,Adenosine Triphosphatase, Myosin,Adenosinetriphosphatase, Actomyosin,Adenosinetriphosphatase, Myosin,Myosin,Myosin Adenosinetriphosphatase,ATPase, Actin Activated,Actin Activated ATPase,Myosin Adenosine Triphosphatase
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D005260 Female Females
D006321 Heart The hollow, muscular organ that maintains the circulation of the blood. Hearts

Related Publications

A Matsumori, and T Yamada, and S Morishima, and N Tamaki, and Y Watanabe, and Y Yonekura, and K Endo, and J Konishi, and A Yoshida, and C Kawai
February 1995, Annals of nuclear medicine,
A Matsumori, and T Yamada, and S Morishima, and N Tamaki, and Y Watanabe, and Y Yonekura, and K Endo, and J Konishi, and A Yoshida, and C Kawai
August 1987, Circulation,
A Matsumori, and T Yamada, and S Morishima, and N Tamaki, and Y Watanabe, and Y Yonekura, and K Endo, and J Konishi, and A Yoshida, and C Kawai
July 1993, International journal of cardiology,
A Matsumori, and T Yamada, and S Morishima, and N Tamaki, and Y Watanabe, and Y Yonekura, and K Endo, and J Konishi, and A Yoshida, and C Kawai
January 1989, European journal of nuclear medicine,
A Matsumori, and T Yamada, and S Morishima, and N Tamaki, and Y Watanabe, and Y Yonekura, and K Endo, and J Konishi, and A Yoshida, and C Kawai
January 2000, The American journal of cardiology,
A Matsumori, and T Yamada, and S Morishima, and N Tamaki, and Y Watanabe, and Y Yonekura, and K Endo, and J Konishi, and A Yoshida, and C Kawai
January 1993, Journal of the American College of Cardiology,
A Matsumori, and T Yamada, and S Morishima, and N Tamaki, and Y Watanabe, and Y Yonekura, and K Endo, and J Konishi, and A Yoshida, and C Kawai
September 1993, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
A Matsumori, and T Yamada, and S Morishima, and N Tamaki, and Y Watanabe, and Y Yonekura, and K Endo, and J Konishi, and A Yoshida, and C Kawai
August 2003, International journal of cardiology,
A Matsumori, and T Yamada, and S Morishima, and N Tamaki, and Y Watanabe, and Y Yonekura, and K Endo, and J Konishi, and A Yoshida, and C Kawai
August 1990, Transplantation proceedings,
A Matsumori, and T Yamada, and S Morishima, and N Tamaki, and Y Watanabe, and Y Yonekura, and K Endo, and J Konishi, and A Yoshida, and C Kawai
June 2003, Nuklearmedizin. Nuclear medicine,
Copied contents to your clipboard!