BIOMAT Database Logo BIOMAT Database Logo

Indium-111 antimyosin monoclonal antibody Fab imaging in patients with cardiomyopathy. 1995

M Ishibashi, and T Wada, and S Morita, and Y Koga, and S Tanaka, and N Umezaki, and H Toshima, and N Hayabuchi
Department of Radiology, Kurume University School of Medicine, Fukuoka, Japan.

Six patients with cardiomyopathy were imaged following intravenous injection of an indium-111 labeled monoclonal antibody directed against the heavy chain of cardiac myosin. Two patients had hypertrophic non-obstructive cardiomyopathy (HNCM), two patients had dilated cardiomyopathy (DCM), and two patients had specific heart muscle disease. One of 2 patients with HNCM and one of 2 patients with DCM had a positive antimyosin scan. The 2 patients with specific heart muscle disease manifested persistent blood pool activity of the antibody, thereby precluding interpretation of the images. The present report demonstrates that antimyosin antibody imaging may provide evidence of myocardial injury, or necrosis in some patients with cardiomyopathy.

UI MeSH Term Description Entries
D007140 Immunoglobulin Fab Fragments Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN. Fab Fragment,Fab Fragments,Ig Fab Fragments,Immunoglobulins, Fab Fragment,Fab Immunoglobulin Fragments,Immunoglobulin Fab Fragment,Immunoglobulins, Fab,Fab Fragment Immunoglobulins,Fab Fragment, Immunoglobulin,Fab Fragments, Immunoglobulin,Fragment Immunoglobulins, Fab,Fragment, Fab,Immunoglobulin Fragments, Fab
D007205 Indium Radioisotopes Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes. Radioisotopes, Indium
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009202 Cardiomyopathies A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS). Myocardial Disease,Myocardial Diseases,Myocardial Diseases, Primary,Myocardial Diseases, Secondary,Myocardiopathies,Primary Myocardial Disease,Cardiomyopathies, Primary,Cardiomyopathies, Secondary,Primary Myocardial Diseases,Secondary Myocardial Diseases,Cardiomyopathy,Cardiomyopathy, Primary,Cardiomyopathy, Secondary,Disease, Myocardial,Disease, Primary Myocardial,Disease, Secondary Myocardial,Diseases, Myocardial,Diseases, Primary Myocardial,Diseases, Secondary Myocardial,Myocardial Disease, Primary,Myocardial Disease, Secondary,Myocardiopathy,Primary Cardiomyopathies,Primary Cardiomyopathy,Secondary Cardiomyopathies,Secondary Cardiomyopathy,Secondary Myocardial Disease
D009218 Myosins A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain. Myosin ATPase,ATPase, Actin-Activated,ATPase, Actomyosin,ATPase, Myosin,Actin-Activated ATPase,Actomyosin ATPase,Actomyosin Adenosinetriphosphatase,Adenosine Triphosphatase, Myosin,Adenosinetriphosphatase, Actomyosin,Adenosinetriphosphatase, Myosin,Myosin,Myosin Adenosinetriphosphatase,ATPase, Actin Activated,Actin Activated ATPase,Myosin Adenosine Triphosphatase
D002311 Cardiomyopathy, Dilated A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein. Cardiomyopathy, Congestive,Congestive Cardiomyopathy,Dilated Cardiomyopathy,Cardiomyopathy, Dilated, 1a,Cardiomyopathy, Dilated, Autosomal Recessive,Cardiomyopathy, Dilated, CMD1A,Cardiomyopathy, Dilated, LMNA,Cardiomyopathy, Dilated, With Conduction Defect 1,Cardiomyopathy, Dilated, with Conduction Deffect1,Cardiomyopathy, Familial Idiopathic,Cardiomyopathy, Idiopathic Dilated,Cardiomyopathies, Congestive,Cardiomyopathies, Dilated,Cardiomyopathies, Familial Idiopathic,Cardiomyopathies, Idiopathic Dilated,Congestive Cardiomyopathies,Dilated Cardiomyopathies,Dilated Cardiomyopathies, Idiopathic,Dilated Cardiomyopathy, Idiopathic,Familial Idiopathic Cardiomyopathies,Familial Idiopathic Cardiomyopathy,Idiopathic Cardiomyopathies, Familial,Idiopathic Cardiomyopathy, Familial,Idiopathic Dilated Cardiomyopathies,Idiopathic Dilated Cardiomyopathy
D002312 Cardiomyopathy, Hypertrophic A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY). Cardiomyopathy, Hypertrophic Obstructive,Cardiomyopathies, Hypertrophic,Cardiomyopathies, Hypertrophic Obstructive,Hypertrophic Cardiomyopathies,Hypertrophic Cardiomyopathy,Hypertrophic Obstructive Cardiomyopathies,Hypertrophic Obstructive Cardiomyopathy,Obstructive Cardiomyopathies, Hypertrophic,Obstructive Cardiomyopathy, Hypertrophic
D003971 Diastole Post-systolic relaxation of the HEART, especially the HEART VENTRICLES. Diastoles
D005260 Female Females

Related Publications

M Ishibashi, and T Wada, and S Morita, and Y Koga, and S Tanaka, and N Umezaki, and H Toshima, and N Hayabuchi
[Indium-111 antimyosin monoclonal antibody uptake in patients with cardiomyopathy and myocarditis].
October 1990, Kaku igaku. The Japanese journal of nuclear medicine,
M Ishibashi, and T Wada, and S Morita, and Y Koga, and S Tanaka, and N Umezaki, and H Toshima, and N Hayabuchi
Acute myocardial infarct imaging with indium-111-labeled monoclonal antimyosin Fab.
November 1987, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
M Ishibashi, and T Wada, and S Morita, and Y Koga, and S Tanaka, and N Umezaki, and H Toshima, and N Hayabuchi
Imaging of soft-tissue sarcomas with indium-111-labeled monoclonal antimyosin Fab fragments.
January 1990, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
M Ishibashi, and T Wada, and S Morita, and Y Koga, and S Tanaka, and N Umezaki, and H Toshima, and N Hayabuchi
Imaging of cardiac allograft rejection in dogs using indium-111 monoclonal antimyosin Fab.
March 1987, Journal of the American College of Cardiology,
M Ishibashi, and T Wada, and S Morita, and Y Koga, and S Tanaka, and N Umezaki, and H Toshima, and N Hayabuchi
Detection of adriamycin cardiotoxicity with indium-111 labeled antimyosin monoclonal antibody imaging.
April 1991, Japanese circulation journal,
M Ishibashi, and T Wada, and S Morita, and Y Koga, and S Tanaka, and N Umezaki, and H Toshima, and N Hayabuchi
Indium 111-monoclonal antimyosin antibody imaging in the diagnosis of acute myocarditis.
August 1987, Circulation,
M Ishibashi, and T Wada, and S Morita, and Y Koga, and S Tanaka, and N Umezaki, and H Toshima, and N Hayabuchi
Detection of human cardiac transplant rejection with indium-111 monoclonal antimyosin antibody imaging.
August 1990, Transplantation proceedings,
M Ishibashi, and T Wada, and S Morita, and Y Koga, and S Tanaka, and N Umezaki, and H Toshima, and N Hayabuchi
Persistent uptake of indium-111-antimyosin monoclonal antibody in patients with myocardial infarction.
November 1990, American heart journal,
M Ishibashi, and T Wada, and S Morita, and Y Koga, and S Tanaka, and N Umezaki, and H Toshima, and N Hayabuchi
Value of indium-111 monoclonal antimyosin antibody for imaging in acute myocardial infarction.
September 1987, The American journal of cardiology,
M Ishibashi, and T Wada, and S Morita, and Y Koga, and S Tanaka, and N Umezaki, and H Toshima, and N Hayabuchi
Indium-111 monoclonal antimyosin cardiac scintigraphy in men with idiopathic dilated cardiomyopathy.
January 2000, The American journal of cardiology,
Copied contents to your clipboard!