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An enzyme electrode (GOD, Pt-Ag/AgCl) is introduced for amperometric measurement of the intracorporal glucose concentration in the subcutaneous tissue. Changes of the glucose concentration in the peripheral blood (PG) were induced by glucose- respectively insulin-infusion in healthy dogs. PG was compared with values found by out means of a sensor implanted in the necks of the dogs (SG). The regression equation SG = 0.81 PG - 1.39 was calculated by analysing 62 steady state levels. The regression delta SG = 0.83 delta PG + 0.22 submitted for the deviation of the normoglycemic base-level. A sensibility loss of the sensor of about 10% appears after an implantation duration of 7.5 hours in medium. Conclusions for the further development of the sensors follows especially with the in vivo functions (biocompatibility, diminution, sterilisation).
E Brunstein, and
P Abel, and
K Rebrin, and
U Fischer
January 1986,
Biomedica biochimica acta,
E Brunstein, and
P Abel, and
K Rebrin, and
U Fischer
April 1977,
Zeitschrift fur medizinische Laboratoriumsdiagnostik,
E Brunstein, and
P Abel, and
K Rebrin, and
U Fischer
September 1983,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
E Brunstein, and
P Abel, and
K Rebrin, and
U Fischer
January 2000,
Journees annuelles de diabetologie de l'Hotel-Dieu,
E Brunstein, and
P Abel, and
K Rebrin, and
U Fischer
September 1973,
Biochimica et biophysica acta,
E Brunstein, and
P Abel, and
K Rebrin, and
U Fischer
January 1983,
Zeitschrift fur medizinische Laboratoriumsdiagnostik,
E Brunstein, and
P Abel, and
K Rebrin, and
U Fischer
November 1979,
Journal of biomedical materials research,
E Brunstein, and
P Abel, and
K Rebrin, and
U Fischer
May 1998,
Analytical chemistry,
E Brunstein, and
P Abel, and
K Rebrin, and
U Fischer
July 2003,
Analytical chemistry,
E Brunstein, and
P Abel, and
K Rebrin, and
U Fischer
May 1967,
Rinsho byori. The Japanese journal of clinical pathology,
