Alkaloids isolated from the lateral root of Aconitum carmichaelii. 2012

Liang Xiong, and Cheng Peng, and Xiao-Fang Xie, and Li Guo, and Cheng-Jun He, and Zhao Geng, and Feng Wan, and Ou Dai, and Qin-Mei Zhou
State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China.

Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.

UI MeSH Term Description Entries
D010424 Pentobarbital A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236) Mebubarbital,Mebumal,Diabutal,Etaminal,Ethaminal,Nembutal,Pentobarbital Sodium,Pentobarbital, Monosodium Salt,Pentobarbitone,Sagatal,Monosodium Salt Pentobarbital
D010936 Plant Extracts Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard. Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D002316 Cardiotonic Agents Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). Cardiac Stimulant,Cardiac Stimulants,Cardioprotective Agent,Cardioprotective Agents,Cardiotonic,Cardiotonic Agent,Cardiotonic Drug,Inotropic Agents, Positive Cardiac,Myocardial Stimulant,Myocardial Stimulants,Cardiotonic Drugs,Cardiotonics,Agent, Cardioprotective,Agent, Cardiotonic,Drug, Cardiotonic,Stimulant, Cardiac,Stimulant, Myocardial
D000470 Alkaloids Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed) Alkaloid,Plant Alkaloid,Plant Alkaloids,Alkaloid, Plant,Alkaloids, Plant
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D018517 Plant Roots The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990) Plant Bulbs,Plant Root,Bulb, Plant,Bulbs, Plant,Plant Bulb,Root, Plant,Roots, Plant
D019906 Nuclear Magnetic Resonance, Biomolecular NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope. Biomolecular Nuclear Magnetic Resonance,Heteronuclear Nuclear Magnetic Resonance,NMR Spectroscopy, Protein,NMR, Biomolecular,NMR, Heteronuclear,NMR, Multinuclear,Nuclear Magnetic Resonance, Heteronuclear,Protein NMR Spectroscopy,Biomolecular NMR,Heteronuclear NMR,Multinuclear NMR,NMR Spectroscopies, Protein,Protein NMR Spectroscopies,Spectroscopies, Protein NMR,Spectroscopy, Protein NMR
D031841 Aconitum A plant genus of the family RANUNCULACEAE. Members contain a number of diterpenoid alkaloids including: aconitans, hypaconitine, ACONITINE, jesaconitine, ignavine, napelline, and mesaconitine. The common name of Wolfbane is similar to the common name for ARNICA. Monkshood,Aconite,Aconitum napellus,Radix Aconiti,Aconites,Aconiti, Radix,Aconitums,Aconitus, Radix,Monkshoods,Radix Aconitus
D032383 Myocytes, Cardiac Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC). Cardiomyocytes,Muscle Cells, Cardiac,Muscle Cells, Heart,Cardiac Muscle Cell,Cardiac Muscle Cells,Cardiac Myocyte,Cardiac Myocytes,Cardiomyocyte,Cell, Cardiac Muscle,Cell, Heart Muscle,Cells, Cardiac Muscle,Cells, Heart Muscle,Heart Muscle Cell,Heart Muscle Cells,Muscle Cell, Cardiac,Muscle Cell, Heart,Myocyte, Cardiac

Related Publications

Liang Xiong, and Cheng Peng, and Xiao-Fang Xie, and Li Guo, and Cheng-Jun He, and Zhao Geng, and Feng Wan, and Ou Dai, and Qin-Mei Zhou
June 2012, Journal of natural products,
Liang Xiong, and Cheng Peng, and Xiao-Fang Xie, and Li Guo, and Cheng-Jun He, and Zhao Geng, and Feng Wan, and Ou Dai, and Qin-Mei Zhou
July 2021, Journal of Asian natural products research,
Liang Xiong, and Cheng Peng, and Xiao-Fang Xie, and Li Guo, and Cheng-Jun He, and Zhao Geng, and Feng Wan, and Ou Dai, and Qin-Mei Zhou
December 2022, Phytochemistry,
Liang Xiong, and Cheng Peng, and Xiao-Fang Xie, and Li Guo, and Cheng-Jun He, and Zhao Geng, and Feng Wan, and Ou Dai, and Qin-Mei Zhou
May 2019, Natural product research,
Liang Xiong, and Cheng Peng, and Xiao-Fang Xie, and Li Guo, and Cheng-Jun He, and Zhao Geng, and Feng Wan, and Ou Dai, and Qin-Mei Zhou
July 2018, Chemistry & biodiversity,
Liang Xiong, and Cheng Peng, and Xiao-Fang Xie, and Li Guo, and Cheng-Jun He, and Zhao Geng, and Feng Wan, and Ou Dai, and Qin-Mei Zhou
April 2019, Journal of natural products,
Liang Xiong, and Cheng Peng, and Xiao-Fang Xie, and Li Guo, and Cheng-Jun He, and Zhao Geng, and Feng Wan, and Ou Dai, and Qin-Mei Zhou
January 2014, Journal of Asian natural products research,
Liang Xiong, and Cheng Peng, and Xiao-Fang Xie, and Li Guo, and Cheng-Jun He, and Zhao Geng, and Feng Wan, and Ou Dai, and Qin-Mei Zhou
January 2016, Iranian journal of pharmaceutical research : IJPR,
Liang Xiong, and Cheng Peng, and Xiao-Fang Xie, and Li Guo, and Cheng-Jun He, and Zhao Geng, and Feng Wan, and Ou Dai, and Qin-Mei Zhou
August 2014, Yao xue xue bao = Acta pharmaceutica Sinica,
Liang Xiong, and Cheng Peng, and Xiao-Fang Xie, and Li Guo, and Cheng-Jun He, and Zhao Geng, and Feng Wan, and Ou Dai, and Qin-Mei Zhou
February 2015, Journal of ethnopharmacology,
Copied contents to your clipboard!