Antiviral activity of aconite alkaloids from Aconitum carmichaelii Debx. 2019

Weiming Xu, and Min Zhang, and Hongwu Liu, and Kun Wei, and Ming He, and Xiangyang Li, and Deyu Hu, and Song Yang, and Yuguo Zheng
a State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education , Guizhou University , Guiyang , PR China.

Four diterpenoid alkaloids, namely, (a) hypaconitine, (b) songorine, (c) mesaconitine and (d) aconitine, were isolated from the ethanol root extract of Aconitum carmichaelii Debx. The antiviral activities of these alkaloids against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) were evaluated. Antiviral activity test in vivo showed that compounds a and c, which were C19-diterpenoid alkaloids, showed inactivation efficacy values of 82.4 and 85.6% against TMV at 500 μg/mL, respectively. By contrast, compound c presented inactivation activity of 52.1% against CMV at 500 μg/mL, which was almost equal to that of the commercial Ningnanmycin (87.1% inactivation activity against TMV and 53.8% inactivation activity against CMV). C19-Diterpenoid alkaloids displayed moderate to high antiviral activity against TMV and CMV at 500 μg/mL, dosage plays an important role in antiviral activities. This paper is the first report on the evolution of aconite diterpenoid alkaloids for antiviral activity against CMV.

UI MeSH Term Description Entries
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004353 Drug Evaluation, Preclinical Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications. Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D000157 Aconitine A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM; DELPHINIUM and larkspurs. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has anti-inflammatory and anti-neuralgic properties. Acetylbenzoylaconine,Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-benzoate, (1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-,Acetylbenzoyl-aconine,Acetylbenzoyl aconine
D000470 Alkaloids Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed) Alkaloid,Plant Alkaloid,Plant Alkaloids,Alkaloid, Plant,Alkaloids, Plant
D000998 Antiviral Agents Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral
D014027 Tobacco Mosaic Virus The type species of TOBAMOVIRUS which causes mosaic disease of NICOTIANA. Transmission occurs by mechanical inoculation. Mosaic Virus, Tobacco,Mosaic Viruses, Tobacco,Tobacco Mosaic Viruses,Virus, Tobacco Mosaic,Viruses, Tobacco Mosaic
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular
D017799 Cucumovirus A genus of plant viruses of the family BROMOVIRIDAE, which infect cucurbits and solanaceous plants. Transmission occurs via aphids in a non-persistent manner, and also via seeds. The type species Cucumber mosaic virus, a CUCUMOVIRUS, should not be confused with Cucumber green mottle mosaic virus, a TOBAMOVIRUS. Cucumber mosaic virus,Cucumber mosaic viruses,Cucumoviruses
D018517 Plant Roots The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990) Plant Bulbs,Plant Root,Bulb, Plant,Bulbs, Plant,Plant Bulb,Root, Plant,Roots, Plant
D031841 Aconitum A plant genus of the family RANUNCULACEAE. Members contain a number of diterpenoid alkaloids including: aconitans, hypaconitine, ACONITINE, jesaconitine, ignavine, napelline, and mesaconitine. The common name of Wolfbane is similar to the common name for ARNICA. Monkshood,Aconite,Aconitum napellus,Radix Aconiti,Aconites,Aconiti, Radix,Aconitums,Aconitus, Radix,Monkshoods,Radix Aconitus

Related Publications

Weiming Xu, and Min Zhang, and Hongwu Liu, and Kun Wei, and Ming He, and Xiangyang Li, and Deyu Hu, and Song Yang, and Yuguo Zheng
July 1966, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
Weiming Xu, and Min Zhang, and Hongwu Liu, and Kun Wei, and Ming He, and Xiangyang Li, and Deyu Hu, and Song Yang, and Yuguo Zheng
December 2022, Plant signaling & behavior,
Weiming Xu, and Min Zhang, and Hongwu Liu, and Kun Wei, and Ming He, and Xiangyang Li, and Deyu Hu, and Song Yang, and Yuguo Zheng
August 2014, Yao xue xue bao = Acta pharmaceutica Sinica,
Weiming Xu, and Min Zhang, and Hongwu Liu, and Kun Wei, and Ming He, and Xiangyang Li, and Deyu Hu, and Song Yang, and Yuguo Zheng
May 2024, Gene,
Weiming Xu, and Min Zhang, and Hongwu Liu, and Kun Wei, and Ming He, and Xiangyang Li, and Deyu Hu, and Song Yang, and Yuguo Zheng
August 2012, Molecules (Basel, Switzerland),
Weiming Xu, and Min Zhang, and Hongwu Liu, and Kun Wei, and Ming He, and Xiangyang Li, and Deyu Hu, and Song Yang, and Yuguo Zheng
June 2012, Journal of natural products,
Weiming Xu, and Min Zhang, and Hongwu Liu, and Kun Wei, and Ming He, and Xiangyang Li, and Deyu Hu, and Song Yang, and Yuguo Zheng
December 2017, Toxicology in vitro : an international journal published in association with BIBRA,
Weiming Xu, and Min Zhang, and Hongwu Liu, and Kun Wei, and Ming He, and Xiangyang Li, and Deyu Hu, and Song Yang, and Yuguo Zheng
July 2018, Chemistry & biodiversity,
Weiming Xu, and Min Zhang, and Hongwu Liu, and Kun Wei, and Ming He, and Xiangyang Li, and Deyu Hu, and Song Yang, and Yuguo Zheng
April 2019, Journal of natural products,
Weiming Xu, and Min Zhang, and Hongwu Liu, and Kun Wei, and Ming He, and Xiangyang Li, and Deyu Hu, and Song Yang, and Yuguo Zheng
June 2017, European journal of drug metabolism and pharmacokinetics,
Copied contents to your clipboard!