The outcomes of treatment of 217 patients aged 50 or over with newly diagnosed destructive pulmonary tuberculosis were analysed. Their management included the following 3 regimens: Groups 1 and 2 were on intermittent regimen with drugs introduced parenterally, and Group 3 was on a daily regimen with drugs introduced orally. The intermittent regimens can compete with a daily one, whereas a parenteral administration of all the three drugs (Group 2) can even surpass it in to its efficacy. Cavity closure rate was registered in 74.2, 81.4 and 60.0% in the Groups 1, 2 and 3, respectively. If compared to a daily oral administration, the intermittent one leads to the elimination of destructive changes in the lungs more rapidly and in a shorter period of time. A significant improvement of tolerance to the intermittent drug administration and a decrease in the prescribed medicinal load on the body are noted.