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Methodological approaches to investigation of low-molecular urine metabolites in health and glomerulonephritis (GN) by means of proton nuclear magnetic resonance spectroscopy (1H NMR) have been analysed. The ways to preserve and concentrate the urine samples by freezing and lyophilization for further storage and spectra quality improvement are substantiated. The method of the spectra treatment with calculation of relative levels of urine substances is detailed. The differences in the ratios of excreted low-molecular metabolites revealed in healthy subjects and GN patients in relation to the severity of chronic renal insufficiency confirm the feasibility of using the 1H NMR data of urine as diagnostic and predictive criteria in GN.
T A Lundina, and
T L Knubovets, and
L A Sibel'dina, and
K R Sedov
January 1999,
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K R Sedov
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T A Lundina, and
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K R Sedov
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T A Lundina, and
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K R Sedov
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T A Lundina, and
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K R Sedov
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