Energy demand of synaptic transmission at the hippocampal Schaffer-collateral synapse. 2012

Agustin Liotta, and Jörg Rösner, and Christine Huchzermeyer, and Anna Wojtowicz, and Oliver Kann, and Dietmar Schmitz, and Uwe Heinemann, and Richard Kovács
Institute for Neurophysiology, Charité-Universitätsmedizin, Berlin, Germany.

Neuroenergetic models of synaptic transmission predicted that energy demand is highest for action potentials (APs) and postsynaptic ion fluxes, whereas the presynaptic contribution is rather small. Here, we addressed the question of energy consumption at Schaffer-collateral synapses. We monitored stimulus-induced changes in extracellular potassium, sodium, and calcium concentration while recording partial oxygen pressure (pO(2)) and NAD(P)H fluorescence. Blockade of postsynaptic receptors reduced ion fluxes as well as pO(2) and NAD(P)H transients by ∼50%. Additional blockade of transmitter release further reduced Na(+), K(+), and pO(2) transients by ∼30% without altering presynaptic APs, indicating considerable contribution of Ca(2+)-removal, transmitter and vesicle turnover to energy consumption.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008297 Male Males
D009249 NADP Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) Coenzyme II,Nicotinamide-Adenine Dinucleotide Phosphate,Triphosphopyridine Nucleotide,NADPH,Dinucleotide Phosphate, Nicotinamide-Adenine,Nicotinamide Adenine Dinucleotide Phosphate,Nucleotide, Triphosphopyridine,Phosphate, Nicotinamide-Adenine Dinucleotide
D009435 Synaptic Transmission The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES. Neural Transmission,Neurotransmission,Transmission, Neural,Transmission, Synaptic
D010101 Oxygen Consumption The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346) Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D011188 Potassium An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D004734 Energy Metabolism The chemical reactions involved in the production and utilization of various forms of energy in cells. Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D005680 gamma-Aminobutyric Acid The most common inhibitory neurotransmitter in the central nervous system. 4-Aminobutyric Acid,GABA,4-Aminobutanoic Acid,Aminalon,Aminalone,Gammalon,Lithium GABA,gamma-Aminobutyric Acid, Calcium Salt (2:1),gamma-Aminobutyric Acid, Hydrochloride,gamma-Aminobutyric Acid, Monolithium Salt,gamma-Aminobutyric Acid, Monosodium Salt,gamma-Aminobutyric Acid, Zinc Salt (2:1),4 Aminobutanoic Acid,4 Aminobutyric Acid,Acid, Hydrochloride gamma-Aminobutyric,GABA, Lithium,Hydrochloride gamma-Aminobutyric Acid,gamma Aminobutyric Acid,gamma Aminobutyric Acid, Hydrochloride,gamma Aminobutyric Acid, Monolithium Salt,gamma Aminobutyric Acid, Monosodium Salt
D005971 Glutamates Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure. Glutamic Acid Derivatives,Glutamic Acids,Glutaminic Acids

Related Publications

Agustin Liotta, and Jörg Rösner, and Christine Huchzermeyer, and Anna Wojtowicz, and Oliver Kann, and Dietmar Schmitz, and Uwe Heinemann, and Richard Kovács
May 2012, European journal of pharmacology,
Agustin Liotta, and Jörg Rösner, and Christine Huchzermeyer, and Anna Wojtowicz, and Oliver Kann, and Dietmar Schmitz, and Uwe Heinemann, and Richard Kovács
April 2007, Neuroscience letters,
Agustin Liotta, and Jörg Rösner, and Christine Huchzermeyer, and Anna Wojtowicz, and Oliver Kann, and Dietmar Schmitz, and Uwe Heinemann, and Richard Kovács
August 2015, Phytomedicine : international journal of phytotherapy and phytopharmacology,
Agustin Liotta, and Jörg Rösner, and Christine Huchzermeyer, and Anna Wojtowicz, and Oliver Kann, and Dietmar Schmitz, and Uwe Heinemann, and Richard Kovács
January 1991, Experimental brain research,
Agustin Liotta, and Jörg Rösner, and Christine Huchzermeyer, and Anna Wojtowicz, and Oliver Kann, and Dietmar Schmitz, and Uwe Heinemann, and Richard Kovács
March 2018, The Journal of physiology,
Agustin Liotta, and Jörg Rösner, and Christine Huchzermeyer, and Anna Wojtowicz, and Oliver Kann, and Dietmar Schmitz, and Uwe Heinemann, and Richard Kovács
January 2006, The Journal of neuroscience : the official journal of the Society for Neuroscience,
Agustin Liotta, and Jörg Rösner, and Christine Huchzermeyer, and Anna Wojtowicz, and Oliver Kann, and Dietmar Schmitz, and Uwe Heinemann, and Richard Kovács
October 1990, Journal of neurophysiology,
Agustin Liotta, and Jörg Rösner, and Christine Huchzermeyer, and Anna Wojtowicz, and Oliver Kann, and Dietmar Schmitz, and Uwe Heinemann, and Richard Kovács
August 2012, The Journal of physiology,
Agustin Liotta, and Jörg Rösner, and Christine Huchzermeyer, and Anna Wojtowicz, and Oliver Kann, and Dietmar Schmitz, and Uwe Heinemann, and Richard Kovács
February 1996, Journal of neurophysiology,
Agustin Liotta, and Jörg Rösner, and Christine Huchzermeyer, and Anna Wojtowicz, and Oliver Kann, and Dietmar Schmitz, and Uwe Heinemann, and Richard Kovács
January 2016, Journal of neurochemistry,
Copied contents to your clipboard!