BIOMAT Database Logo BIOMAT Database Logo

Regulation of the anti-Sm autoantibody response in systemic lupus erythematosus mice by monoclonal anti-Sm antibodies. 1990

R A Eisenberg, and D S Pisetsky, and S Y Craven, and J P Grudier, and M A O'Donnell, and P L Cohen
Department of Medicine, University of North Carolina, Chapel Hill 27599.

The administration of certain monoclonal anti-Sm antibodies (2G7, 7.13) induced most MRL/lpr mice to become anti-Sm positive by 5 mo of age, although other anti-Sm monoclonals (Y2, Y12) suppressed the spontaneous response. Positive anti-Sm antibody enhancement occurred efficiently only in MRL/lpr mice and not in other systemic lupus erythematosus mice that have little spontaneous anti-Sm production. The enhancement by anti-Sm antibodies was specific for the anti-Sm response. The mechanism of the passive antibody enhancement was apparently not isotype- or idiotype-related. The fine specificity of the anti-Sm monoclonal antibody may be essential to its enhancing or suppressing effects, since both enhancing monoclonals recognized only the D Sm polypeptide, whereas both suppressing monoclonals saw the D and the B polypeptides. Furthermore, analysis of serial bleeds from unmanipulated MRL mice that developed anti-Sm positivity showed that the D specificity almost always appeared first. We hypothesize, therefore, that those animals in which an anti-Sm response is initiated by D-specific B-cell clones can become serologically positive with the aid of a positive feedback loop. In contrast, animals in which the initial specificity is for both B and D peptides would be prevented from developing a full anti-Sm response.

UI MeSH Term Description Entries
D007130 Immunoglobulin Idiotypes Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains. Idiotypes, Immunoglobulin,Ig Idiotypes,Idiotype, Ig,Idiotype, Immunoglobulin,Idiotypes, Ig,Ig Idiotype,Immunoglobulin Idiotype
D008180 Lupus Erythematosus, Systemic A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D008815 Mice, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation. Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000911 Antibodies, Monoclonal Antibodies produced by a single clone of cells. Monoclonal Antibodies,Monoclonal Antibody,Antibody, Monoclonal
D000917 Antibody Formation The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS. Antibody Production,Antibody Response,Antibody Responses,Formation, Antibody,Production, Antibody,Response, Antibody,Responses, Antibody
D001323 Autoantibodies Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them. Autoantibody
D013045 Species Specificity The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species. Species Specificities,Specificities, Species,Specificity, Species
D015151 Immunoblotting Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies. Dot Immunoblotting,Electroimmunoblotting,Immunoelectroblotting,Reverse Immunoblotting,Immunoblotting, Dot,Immunoblotting, Reverse,Dot Immunoblottings,Electroimmunoblottings,Immunoblottings,Immunoblottings, Dot,Immunoblottings, Reverse,Immunoelectroblottings,Reverse Immunoblottings

Related Publications

R A Eisenberg, and D S Pisetsky, and S Y Craven, and J P Grudier, and M A O'Donnell, and P L Cohen
[Anti-Sm antibodies--marker antibodies in systemic lupus erythematosus (SLE)].
June 2002, Zeitschrift fur Rheumatologie,
R A Eisenberg, and D S Pisetsky, and S Y Craven, and J P Grudier, and M A O'Donnell, and P L Cohen
Clinical significance of anti-Sm antibodies in systemic lupus erythematosus.
February 1983, The American journal of medicine,
R A Eisenberg, and D S Pisetsky, and S Y Craven, and J P Grudier, and M A O'Donnell, and P L Cohen
Anti-Sm antibodies in the classification criteria of systemic lupus erythematosus.
January 2022, Journal of translational autoimmunity,
R A Eisenberg, and D S Pisetsky, and S Y Craven, and J P Grudier, and M A O'Donnell, and P L Cohen
Anti-CD20 monoclonal antibodies in Systemic Lupus Erythematosus.
January 2021, Biologicals : journal of the International Association of Biological Standardization,
R A Eisenberg, and D S Pisetsky, and S Y Craven, and J P Grudier, and M A O'Donnell, and P L Cohen
Induction of experimental systemic lupus erythematosus in mice by immunization with a monoclonal anti-La autoantibody.
January 1990, International immunology,
R A Eisenberg, and D S Pisetsky, and S Y Craven, and J P Grudier, and M A O'Donnell, and P L Cohen
Anti-BB'-Sm antibodies, anticardiolipin antibodies, and thrombosis in systemic lupus erythematosus.
September 1998, The Journal of rheumatology,
R A Eisenberg, and D S Pisetsky, and S Y Craven, and J P Grudier, and M A O'Donnell, and P L Cohen
Complement activation by antibodies to Sm in systemic lupus erythematosus.
February 1983, Clinical and experimental immunology,
R A Eisenberg, and D S Pisetsky, and S Y Craven, and J P Grudier, and M A O'Donnell, and P L Cohen
Differential induction of lupus associated antinuclear antibodies in MRL mice by monoclonal anti-Sm antibodies.
March 1987, Clinical and experimental immunology,
R A Eisenberg, and D S Pisetsky, and S Y Craven, and J P Grudier, and M A O'Donnell, and P L Cohen
Suppression of experimental antiphospholipid syndrome and systemic lupus erythematosus in mice by anti-CD4 monoclonal antibodies.
August 1994, Arthritis and rheumatism,
R A Eisenberg, and D S Pisetsky, and S Y Craven, and J P Grudier, and M A O'Donnell, and P L Cohen
Anti-dsDNA and anti-Sm antibodies do not predict damage in systemic lupus erythematosus.
January 2006, Lupus,
Copied contents to your clipboard!