-transparent.png){kind=logo}
To examine the effect of nonadrenergic noncholinergic (NANC) inhibitory nerve stimulation on the antigen inhalation with allergic animals, changes in pulmonary resistance (RL) and arterial plasma histamine concentration ([H]) caused by inhalation of Ascaris suum antigen were studied in five control (Group A) and five nerve-stimulated (Group B) cats, which were anesthetized and mechanically ventilated. All animals were actively sensitized with Ascaris antigen before the experiment. After cholinergic and beta-adrenergic blockade with intravenously administered atropine (3 mg/kg) and propranolol (2 mg/kg), inhalation of the antigen (1:100 dilution) was performed for 3 min. For Group B, bilateral cervical vagi were stimulated electrically for 1 min before the antigen inhalation and successively every 30 s until 5 min had passed from the onset of inhalation. RL and [H] were determined before, during, and after antigen inhalation in both groups. Baseline RL and [H] did not differ significantly between groups (16.3 +/- 2.2 (mean +/- SE) cm H2O/L/s and 14.0 +/- 0.7 ng/ml, respectively, for Group A; 14.4 +/- 1.3 and 15.6 +/- 2.7, respectively, for Group B). Increases in RL and [H] of Group B after the antigen inhalation were significantly depressed, compared with Group A (p less than 0.01 and p less than 0.05, respectively, two-way ANOVA). The increase in RL 5 min after antigen inhalation was 113 +/- 19% for Group A and 28 +/- 8% for Group B, and the increase in [H] at the same point was 36.3 +/- 9.1 ng/ml for Group A and 4.4 +/- 1.4 ng/ml for Group B.(ABSTRACT TRUNCATED AT 250 WORDS)
M Miura, and
H Inoue, and
M Ichinose, and
K Kimura, and
U Katsumata, and
T Takishima
August 1985,
European journal of pharmacology,
M Miura, and
H Inoue, and
M Ichinose, and
K Kimura, and
U Katsumata, and
T Takishima
June 1986,
The American review of respiratory disease,
M Miura, and
H Inoue, and
M Ichinose, and
K Kimura, and
U Katsumata, and
T Takishima
May 1994,
Pediatric pulmonology,
M Miura, and
H Inoue, and
M Ichinose, and
K Kimura, and
U Katsumata, and
T Takishima
February 1992,
The European respiratory journal,
M Miura, and
H Inoue, and
M Ichinose, and
K Kimura, and
U Katsumata, and
T Takishima
January 1988,
Peptides,
M Miura, and
H Inoue, and
M Ichinose, and
K Kimura, and
U Katsumata, and
T Takishima
January 1990,
Archives internationales de pharmacodynamie et de therapie,
M Miura, and
H Inoue, and
M Ichinose, and
K Kimura, and
U Katsumata, and
T Takishima
April 1989,
Journal of applied physiology (Bethesda, Md. : 1985),
M Miura, and
H Inoue, and
M Ichinose, and
K Kimura, and
U Katsumata, and
T Takishima
June 1988,
Chest,
M Miura, and
H Inoue, and
M Ichinose, and
K Kimura, and
U Katsumata, and
T Takishima
October 1980,
Experientia,
M Miura, and
H Inoue, and
M Ichinose, and
K Kimura, and
U Katsumata, and
T Takishima
May 1986,
Arerugi = [Allergy],
