Relay simulated moving bed chromatography: concept and design criteria. 2012

Ricardo J S Silva, and Rui C R Rodrigues, and José P B Mota
Requimte/CQFB, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.

We present a new class of multicolumn chromatographic processes that change the classical way of handling the product outlets of simulated moving-bed (SMB) chromatography to avoid the use of flow controllers or an extra pump-the objective is to have just two- or three-way valves at a column outlet-while maintaining the analogy with the SMB in terms of displaced volumes of fluid per switch interval. In this class of processes the flow through a zone (or column) is always in one of the three states: (i) frozen, (ii) completely directed to the next zone (or column), or (iii) entirely diverted to a product line. We use the term relayed stream to refer to this particular type of manipulation of the outflow from a column. For this class of processes we derive a SMB analog-the R-SMB process-and demonstrate, under the framework of the equilibrium theory, that this process has the same separation region as the classical SMB for linear adsorption systems. In addition, the results from the equilibrium theory show that the R-SMB process consists of two distinct cycles that differ only in their intermediate sub-step: one cycle for selectivities α smaller than (3+√5)/2 and another cycle for larger values of α; in the former case no product stream is collected during the intermediate sub-step, whereas in the latter case both product streams are collected. We also examine the R-SMB process under conditions of finite column efficiency and compare its performance against those of the classical open- and closed-loop SMBs. Our simulation results show that the R-SMB process requires less desorbent and is more productive than the standard SMB processes under conditions of finite column efficiency and that the comparison increasingly favors the R-SMB as the column efficiency decreases.

UI MeSH Term Description Entries
D008962 Models, Theoretical Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment. Experimental Model,Experimental Models,Mathematical Model,Model, Experimental,Models (Theoretical),Models, Experimental,Models, Theoretic,Theoretical Study,Mathematical Models,Model (Theoretical),Model, Mathematical,Model, Theoretical,Models, Mathematical,Studies, Theoretical,Study, Theoretical,Theoretical Model,Theoretical Models,Theoretical Studies
D012107 Research Design A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly. Experimental Design,Data Adjustment,Data Reporting,Design, Experimental,Designs, Experimental,Error Sources,Experimental Designs,Matched Groups,Methodology, Research,Problem Formulation,Research Methodology,Research Proposal,Research Strategy,Research Technics,Research Techniques,Scoring Methods,Adjustment, Data,Adjustments, Data,Data Adjustments,Design, Research,Designs, Research,Error Source,Formulation, Problem,Formulations, Problem,Group, Matched,Groups, Matched,Matched Group,Method, Scoring,Methods, Scoring,Problem Formulations,Proposal, Research,Proposals, Research,Reporting, Data,Research Designs,Research Proposals,Research Strategies,Research Technic,Research Technique,Scoring Method,Source, Error,Sources, Error,Strategies, Research,Strategy, Research,Technic, Research,Technics, Research,Technique, Research,Techniques, Research
D002845 Chromatography Techniques used to separate mixtures of substances based on differences in the relative affinities of the substances for mobile and stationary phases. A mobile phase (fluid or gas) passes through a column containing a stationary phase of porous solid or liquid coated on a solid support. Usage is both analytical for small amounts and preparative for bulk amounts. Chromatographies
D003198 Computer Simulation Computer-based representation of physical systems and phenomena such as chemical processes. Computational Modeling,Computational Modelling,Computer Models,In silico Modeling,In silico Models,In silico Simulation,Models, Computer,Computerized Models,Computer Model,Computer Simulations,Computerized Model,In silico Model,Model, Computer,Model, Computerized,Model, In silico,Modeling, Computational,Modeling, In silico,Modelling, Computational,Simulation, Computer,Simulation, In silico,Simulations, Computer
D000327 Adsorption The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily. Adsorptions

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