-transparent.png){kind=logo}
Transgenic mice containing a human fetal (gamma-) or adult (beta-) globin gene linked to the beta-globin gene locus activation region (LAR) express the gene throughout development. By contrast, transgenic mice containing LAR linked to both a fetal and an adult globin gene display the normal developmental switch from fetal to adult gene expression. This suggests that the human fetal-to-adult globin gene switch is controlled through a mutually exclusive interaction between LAR and either the gamma- or beta-globin gene, resulting in the expression of only one gene at any given moment.
Related Publications
T Enver, and
N Raich, and
A J Ebens, and
T Papayannopoulou, and
F Costantini, and
G Stamatoyannopoulos
November 1991,
Developmental biology,
T Enver, and
N Raich, and
A J Ebens, and
T Papayannopoulou, and
F Costantini, and
G Stamatoyannopoulos
July 1993,
Biochemical and biophysical research communications,
T Enver, and
N Raich, and
A J Ebens, and
T Papayannopoulou, and
F Costantini, and
G Stamatoyannopoulos
January 1985,
Nature,
T Enver, and
N Raich, and
A J Ebens, and
T Papayannopoulou, and
F Costantini, and
G Stamatoyannopoulos
December 1990,
Nucleic acids research,
T Enver, and
N Raich, and
A J Ebens, and
T Papayannopoulou, and
F Costantini, and
G Stamatoyannopoulos
March 1990,
Genes & development,
T Enver, and
N Raich, and
A J Ebens, and
T Papayannopoulou, and
F Costantini, and
G Stamatoyannopoulos
January 1985,
Cold Spring Harbor symposia on quantitative biology,
T Enver, and
N Raich, and
A J Ebens, and
T Papayannopoulou, and
F Costantini, and
G Stamatoyannopoulos
December 1993,
Molecular and cellular biology,
T Enver, and
N Raich, and
A J Ebens, and
T Papayannopoulou, and
F Costantini, and
G Stamatoyannopoulos
January 1997,
Blood,
T Enver, and
N Raich, and
A J Ebens, and
T Papayannopoulou, and
F Costantini, and
G Stamatoyannopoulos
October 1988,
Cell,
T Enver, and
N Raich, and
A J Ebens, and
T Papayannopoulou, and
F Costantini, and
G Stamatoyannopoulos
September 1989,
Proceedings of the National Academy of Sciences of the United States of America,
