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The immunoreactive (RIA), ACTH, LPH, alpha endorphin (alpha End) and beta End in an extract of a human pancreatic islet cell carcinoma causing the ectopic ACTH syndrome were assayed after gel exclusion chromatography. In addition to "big", "intermediate" and "little" ACTHs, beta lipotropin (beta LPH) and gamma LPH, the eluate fractions contained RIA-alpha End and -beta End. The major RIA-beta End component appeared to be h beta LPH, which has beta End as its carboxy-terminus, but significant concentrations of a component that coeluted with synthetic p beta End were also found. Small amounts of RIA-alpha End were found in two peaks, one that may have represented 1-76 h beta LPH, with alpha End as its carboxy-terminus, and one probably representing alpha End itself. RIA-ACTH, -LPH and -beta End were found in the void volume fractions. Thus, a human nonpituitary tumor that produced ACTH and LPHs also produced endorphins, all perhaps deriving from a common precursor.
D N Orth, and
R Guillemin, and
N Ling, and
W E Nicholson
December 1978,
Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille,
D N Orth, and
R Guillemin, and
N Ling, and
W E Nicholson
July 1977,
Proceedings of the National Academy of Sciences of the United States of America,
D N Orth, and
R Guillemin, and
N Ling, and
W E Nicholson
October 1978,
Proceedings of the National Academy of Sciences of the United States of America,
D N Orth, and
R Guillemin, and
N Ling, and
W E Nicholson
April 1979,
Proceedings of the National Academy of Sciences of the United States of America,
D N Orth, and
R Guillemin, and
N Ling, and
W E Nicholson
January 1989,
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion,
D N Orth, and
R Guillemin, and
N Ling, and
W E Nicholson
February 1979,
Proceedings of the National Academy of Sciences of the United States of America,
D N Orth, and
R Guillemin, and
N Ling, and
W E Nicholson
February 1978,
The Journal of biological chemistry,
D N Orth, and
R Guillemin, and
N Ling, and
W E Nicholson
July 1978,
The Journal of clinical investigation,
D N Orth, and
R Guillemin, and
N Ling, and
W E Nicholson
January 1984,
Pharmacology & therapeutics,
D N Orth, and
R Guillemin, and
N Ling, and
W E Nicholson
August 1979,
The Journal of biological chemistry,
