-transparent.png){kind=logo}
The mutagenicity of 3-tert-butyl-4-hydroxyanisole (BHA) and its metabolites was investigated in the reverse mutation assay using S. typhimurium strains and the chromosomal aberration test in vitro using a Chinese hamster fibroblast cell line, CHL. BHA, tert-butylhydroquinone (BHQ), tert-butylquinone (BQ) and BHA dimer (diBHA) did not show any mutagenic potential with and without S9 mix in the reverse mutation assay. In addition to the above 4 chemicals, 3-tert-butyl-4,5-dihydroxyanisole (BHA-OH), 3-tert-butylanisole-4,5-quinone (BHA-o-Q), and tert-butylquinone oxide (BQO) were tested in the chromosomal aberration test. BHA, BHQ and BQ induced chromosomal aberrations only in the presence of S9 mix, while BHA-OH, BHA-o-Q and BQO induced chromosomal aberrations only without S9 mix. DiBHA, however, showed no clastogenic potential with and without S9 mix. The present findings suggest that BHA-OH, BHA-o-Q or BQO may contribute to the clastogenicity of BHA in the presence of S9 mix.
A Matsuoka, and
M Matsui, and
N Miyata, and
T Sofuni, and
M Ishidate
November 1984,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
A Matsuoka, and
M Matsui, and
N Miyata, and
T Sofuni, and
M Ishidate
November 1990,
Carcinogenesis,
A Matsuoka, and
M Matsui, and
N Miyata, and
T Sofuni, and
M Ishidate
May 1997,
Cancer letters,
A Matsuoka, and
M Matsui, and
N Miyata, and
T Sofuni, and
M Ishidate
March 1977,
Journal of chromatography,
A Matsuoka, and
M Matsui, and
N Miyata, and
T Sofuni, and
M Ishidate
May 1992,
FEBS letters,
A Matsuoka, and
M Matsui, and
N Miyata, and
T Sofuni, and
M Ishidate
August 1985,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
A Matsuoka, and
M Matsui, and
N Miyata, and
T Sofuni, and
M Ishidate
August 1994,
European journal of pharmacology,
A Matsuoka, and
M Matsui, and
N Miyata, and
T Sofuni, and
M Ishidate
November 1985,
Biochemical pharmacology,
A Matsuoka, and
M Matsui, and
N Miyata, and
T Sofuni, and
M Ishidate
June 1987,
Research communications in chemical pathology and pharmacology,
A Matsuoka, and
M Matsui, and
N Miyata, and
T Sofuni, and
M Ishidate
October 1994,
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology,
