Travelling waves for a velocity-jump model of cell migration and proliferation. 2013

Matthew J Simpson, and Brody H Foy, and Scott W McCue
School of Mathematical Sciences, Queensland University of Technology, G.P.O. Box 2434, Brisbane, Queensland 4001, Australia. matthew.simpson@qut.edu.au

Cell invasion, characterised by moving fronts of cells, is an essential aspect of development, repair and disease. Typically, mathematical models of cell invasion are based on the Fisher-Kolmogorov equation. These traditional parabolic models cannot be used to represent experimental measurements of individual cell velocities within the invading population since they imply that information propagates with infinite speed. To overcome this limitation we study combined cell motility and proliferation based on a velocity-jump process where information propagates with finite speed. The model treats the total population of cells as two interacting subpopulations: a subpopulation of left-moving cells, L(x,t), and a subpopulation of right-moving cells, R(x,t). This leads to a system of hyperbolic partial differential equations that includes a turning rate, Λ⩾0, describing the rate at which individuals in the population change direction of movement. We present exact travelling wave solutions of the system of partial differential equations for the special case where Λ=0 and in the limit that Λ→∞. For intermediate turning rates, 0<Λ<∞, we analyse the travelling waves using the phase plane and we demonstrate a transition from smooth monotone travelling waves to smooth nonmonotone travelling waves as Λ decreases through a critical value Λcrit. We conclude by providing a qualitative comparison between the travelling wave solutions of our model and experimental observations of cell invasion. This comparison indicates that the small Λ limit produces results that are consistent with experimental observations.

UI MeSH Term Description Entries
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D009361 Neoplasm Invasiveness Ability of neoplasms to infiltrate and actively destroy surrounding tissue. Invasiveness, Neoplasm,Neoplasm Invasion,Invasion, Neoplasm
D002465 Cell Movement The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell. Cell Migration,Locomotion, Cell,Migration, Cell,Motility, Cell,Movement, Cell,Cell Locomotion,Cell Motility,Cell Movements,Movements, Cell
D004058 Diffusion The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT. Diffusions
D049109 Cell Proliferation All of the processes involved in increasing CELL NUMBER including CELL DIVISION. Cell Growth in Number,Cellular Proliferation,Cell Multiplication,Cell Number Growth,Growth, Cell Number,Multiplication, Cell,Number Growth, Cell,Proliferation, Cell,Proliferation, Cellular

Related Publications

Matthew J Simpson, and Brody H Foy, and Scott W McCue
May 2024, Journal of mathematical biology,
Matthew J Simpson, and Brody H Foy, and Scott W McCue
October 2007, Bulletin of mathematical biology,
Matthew J Simpson, and Brody H Foy, and Scott W McCue
December 2015, Acta biotheoretica,
Matthew J Simpson, and Brody H Foy, and Scott W McCue
May 2018, Royal Society open science,
Matthew J Simpson, and Brody H Foy, and Scott W McCue
April 2001, Mathematical biosciences,
Matthew J Simpson, and Brody H Foy, and Scott W McCue
January 1994, Journal of mathematical biology,
Matthew J Simpson, and Brody H Foy, and Scott W McCue
April 2014, Journal of mathematical biology,
Matthew J Simpson, and Brody H Foy, and Scott W McCue
April 2019, Bulletin of mathematical biology,
Matthew J Simpson, and Brody H Foy, and Scott W McCue
June 2017, Physica D. Nonlinear phenomena,
Matthew J Simpson, and Brody H Foy, and Scott W McCue
January 2016, Computer methods in biomechanics and biomedical engineering,
Copied contents to your clipboard!