-transparent.png){kind=logo}
Bordetella pertussis produces several potential virulence factors. One of these is an adenylate cyclase which penetrates eukaryotic cells, is activated by calmodulin and generates high levels of intracellular cAMP. We have found that pertussis infection in man leads to production of high titres (2000-8000) of anti-B. pertussis adenylate cyclase antibodies. Such antibodies also are produced after pertussis vaccination. They persist into adulthood, cross the placenta and disappear a few months after birth. The anti-adenylate cyclase antibodies found in human serum during pertussis infection do not neutralise the catalytic and penetrative activities of the enzyme.
Related Publications
Z Farfel, and
S Könen, and
E Wiertz, and
R Klapmuts, and
P A Addy, and
E Hanski
April 1993,
FEMS immunology and medical microbiology,
Z Farfel, and
S Könen, and
E Wiertz, and
R Klapmuts, and
P A Addy, and
E Hanski
March 1992,
Microbial pathogenesis,
Z Farfel, and
S Könen, and
E Wiertz, and
R Klapmuts, and
P A Addy, and
E Hanski
June 1976,
Proceedings of the National Academy of Sciences of the United States of America,
Z Farfel, and
S Könen, and
E Wiertz, and
R Klapmuts, and
P A Addy, and
E Hanski
January 1985,
Journal of general microbiology,
Z Farfel, and
S Könen, and
E Wiertz, and
R Klapmuts, and
P A Addy, and
E Hanski
May 1999,
Infection and immunity,
Z Farfel, and
S Könen, and
E Wiertz, and
R Klapmuts, and
P A Addy, and
E Hanski
November 1989,
Trends in biochemical sciences,
Z Farfel, and
S Könen, and
E Wiertz, and
R Klapmuts, and
P A Addy, and
E Hanski
February 1992,
The Journal of biological chemistry,
Z Farfel, and
S Könen, and
E Wiertz, and
R Klapmuts, and
P A Addy, and
E Hanski
January 1983,
Transactions of the Association of American Physicians,
Z Farfel, and
S Könen, and
E Wiertz, and
R Klapmuts, and
P A Addy, and
E Hanski
January 1978,
Advances in cyclic nucleotide research,
Z Farfel, and
S Könen, and
E Wiertz, and
R Klapmuts, and
P A Addy, and
E Hanski
May 2013,
Infection and immunity,
