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Estimating tulathromycin withdrawal time in pigs using a physiologically based pharmacokinetics model. 2013

F Yang, and X H Huang, and G H Li, and H J Ni, and Y D Zhao, and H Z Ding, and Z L Zeng
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, PR China.

A physiologically based pharmacokinetics model was developed to predict tulathromycin concentrations in edible swine tissues. Physiological parameters included volumes of and plasma flows through different tissues which were obtained from the literatures. The tissue/plasma partition coefficient was calculated according to the area method, and the model was validated through a comparison of predicted and observed concentrations. Withdrawal times in different tissues were predicted. The physiologically based pharmacokinetics model presented here provided accurate predictions of the observed concentrations in all tissues. The results showed that the injection site had the longest withdrawal time (21 days), followed by skin together with fat (19 days) and then kidney (10 days), lung (6 days), liver (4 days) and muscle (1 day). A withdrawal time of 21 days was finally predicted for tulathromycin in swine after a single intramuscular injection at 2.5 mg/kg body weight.

UI MeSH Term Description Entries
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D004187 Disaccharides Oligosaccharides containing two monosaccharide units linked by a glycosidic bond. Disaccharide
D006571 Heterocyclic Compounds Cyclic compounds that include atoms other than carbon in their ring structure. Heterocyclic Compound,Compound, Heterocyclic,Compounds, Heterocyclic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013375 Substance Withdrawal Syndrome Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug. Drug Withdrawal Symptoms,Withdrawal Symptoms,Drug Withdrawal Symptom,Substance Withdrawal Syndromes,Symptom, Drug Withdrawal,Symptom, Withdrawal,Symptoms, Drug Withdrawal,Symptoms, Withdrawal,Syndrome, Substance Withdrawal,Syndromes, Substance Withdrawal,Withdrawal Symptom,Withdrawal Symptom, Drug,Withdrawal Symptoms, Drug,Withdrawal Syndrome, Substance,Withdrawal Syndromes, Substance
D013552 Swine Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA). Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog

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