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Erythrocyte deformability was assessed in 40 diabetic patients, 24 insulin-dependent (IDD) and 16 non-insulin-dependent (NIDD), by measuring the initial filtration flow rate of whole blood, isolated red blood cells (RBC), and isolated RBC membranes with the Hanss hemorheometer, and its relationship to the plasma and ghost membrane lipid composition was investigated. RBC deformability was significantly reduced, whereas the deformability of the isolated RBC membranes did not differ significantly from the controls. In the plasma, the triglycerides were high, the high-density lipoprotein (HDL) cholesterol was reduced, and the ratio of total cholesterol over HDL cholesterol was high as compared with the controls. The RBC lipid composition expressed in mumol lipids/10(10) RBC showed significantly lower levels of free cholesterol, sphingomyelines, and phosphatidylcholine, which are the lipids principally located on the outer layer of the RBC membranes. These data suggest that in both IDD and NIDD patients, there may be a relation between these modifications in the RBC lipid composition and rheological impairment of the RBC.
M Garnier, and
J R Attali, and
P Valensi, and
E Delatour-Hanss, and
F Gaudey, and
D Koutsouris
January 1991,
Zhonghua yi xue za zhi,
M Garnier, and
J R Attali, and
P Valensi, and
E Delatour-Hanss, and
F Gaudey, and
D Koutsouris
November 1987,
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M Garnier, and
J R Attali, and
P Valensi, and
E Delatour-Hanss, and
F Gaudey, and
D Koutsouris
September 1978,
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M Garnier, and
J R Attali, and
P Valensi, and
E Delatour-Hanss, and
F Gaudey, and
D Koutsouris
March 1989,
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M Garnier, and
J R Attali, and
P Valensi, and
E Delatour-Hanss, and
F Gaudey, and
D Koutsouris
January 1980,
Biochemistry and experimental biology,
M Garnier, and
J R Attali, and
P Valensi, and
E Delatour-Hanss, and
F Gaudey, and
D Koutsouris
January 1970,
The Journal of laboratory and clinical medicine,
M Garnier, and
J R Attali, and
P Valensi, and
E Delatour-Hanss, and
F Gaudey, and
D Koutsouris
January 1989,
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M Garnier, and
J R Attali, and
P Valensi, and
E Delatour-Hanss, and
F Gaudey, and
D Koutsouris
January 1981,
Scandinavian journal of clinical and laboratory investigation. Supplementum,
M Garnier, and
J R Attali, and
P Valensi, and
E Delatour-Hanss, and
F Gaudey, and
D Koutsouris
March 1979,
Blood,
M Garnier, and
J R Attali, and
P Valensi, and
E Delatour-Hanss, and
F Gaudey, and
D Koutsouris
December 1989,
Diabetes,
