Pathoembryogenesis of terminal myelocystocele: terminal balloon in secondary neurulation of the chick embryo. 2013

Ji Yeoun Lee, and Saet Pyoul Kim, and Shin Won Kim, and Sung-Hye Park, and Jung Won Choi, and Ji Hoon Phi, and Seung-Ki Kim, and Dachling Pang, and Kyu-Chang Wang
Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-769, Republic of Korea.

OBJECTIVE Terminal myelocystocele (TMC) is thought to be caused by a misstep during secondary neurulation. However, due to the paucity of data on secondary neurulation and the rarity of TMC, proofs of this pathogenetic mechanism are unavailable. Based on a previous observation that TMC resembles a step of secondary neurulation in chick, a closer look was taken at secondary neurulation of chick embryos focusing on the cerebrospinal fluid-filled distal neural tube (terminal balloon). METHODS Chick embryos at Hamburger and Hamilton (H-H) stages of 28, 30, 33, 35, 37, and 40 were harvested. Hematoxying-eosin staining, additional immunohistochemistry (laminin, cytokeratin, nestin), and scanning electron microscopy were performed. RESULTS In H-H stages 28 to 30, after merging of the lumina of the primary and secondary neural tubes, the caudal end of the confluent tube dilates into a balloon-like structure (terminal balloon). As the proximal tube progressively becomes narrower, the terminal balloon dilates even further, and its wall fuses with the surface ectoderm (H-H stage 33). Later in H-H stages 35 to 40, the terminal balloon shrinks and becomes detached from the surface ectoderm and ultimately disappears, as the proximal lumen of the secondary neural tube continues to collapse. CONCLUSIONS A dilated balloon doubtlessly exists in the terminal secondary neural tube in chick embryos, and its subsequent disappearance occurs in a variable time course and sequence. Arrest of apoptosis resulting in failure of detachment of the terminal balloon from the surface ectoderm may well be the basis for human TMC.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008591 Meningomyelocele Congenital, or rarely acquired, herniation of meningeal and spinal cord tissue through a bony defect in the vertebral column. The majority of these defects occur in the lumbosacral region. Clinical features include PARAPLEGIA, loss of sensation in the lower body, and incontinence. This condition may be associated with the ARNOLD-CHIARI MALFORMATION and HYDROCEPHALUS. (From Joynt, Clinical Neurology, 1992, Ch55, pp35-6) Myelocele,Myelomeningocele,Acquired Meningomyelocele,Myelomeningocele, Acquired,Acquired Meningomyeloceles,Acquired Myelomeningocele,Acquired Myelomeningoceles,Meningomyelocele, Acquired,Meningomyeloceles,Meningomyeloceles, Acquired,Myeloceles,Myelomeningoceles,Myelomeningoceles, Acquired
D008855 Microscopy, Electron, Scanning Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY. Scanning Electron Microscopy,Electron Scanning Microscopy,Electron Microscopies, Scanning,Electron Microscopy, Scanning,Electron Scanning Microscopies,Microscopies, Electron Scanning,Microscopies, Scanning Electron,Microscopy, Electron Scanning,Microscopy, Scanning Electron,Scanning Electron Microscopies,Scanning Microscopies, Electron,Scanning Microscopy, Electron
D002642 Chick Embryo The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching. Embryo, Chick,Chick Embryos,Embryos, Chick
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013116 Spinal Cord A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER. Coccygeal Cord,Conus Medullaris,Conus Terminalis,Lumbar Cord,Medulla Spinalis,Myelon,Sacral Cord,Thoracic Cord,Coccygeal Cords,Conus Medullari,Conus Terminali,Cord, Coccygeal,Cord, Lumbar,Cord, Sacral,Cord, Spinal,Cord, Thoracic,Cords, Coccygeal,Cords, Lumbar,Cords, Sacral,Cords, Spinal,Cords, Thoracic,Lumbar Cords,Medulla Spinali,Medullari, Conus,Medullaris, Conus,Myelons,Sacral Cords,Spinal Cords,Spinali, Medulla,Spinalis, Medulla,Terminali, Conus,Terminalis, Conus,Thoracic Cords
D054261 Neurulation An early embryonic developmental process of CHORDATES that is characterized by morphogenic movements of ECTODERM resulting in the formation of the NEURAL PLATE; the NEURAL CREST; and the NEURAL TUBE. Improper closure of the NEURAL GROOVE results in congenital NEURAL TUBE DEFECTS.

Related Publications

Ji Yeoun Lee, and Saet Pyoul Kim, and Shin Won Kim, and Sung-Hye Park, and Jung Won Choi, and Ji Hoon Phi, and Seung-Ki Kim, and Dachling Pang, and Kyu-Chang Wang
January 2023, Advances and technical standards in neurosurgery,
Ji Yeoun Lee, and Saet Pyoul Kim, and Shin Won Kim, and Sung-Hye Park, and Jung Won Choi, and Ji Hoon Phi, and Seung-Ki Kim, and Dachling Pang, and Kyu-Chang Wang
May 1980, The American journal of anatomy,
Ji Yeoun Lee, and Saet Pyoul Kim, and Shin Won Kim, and Sung-Hye Park, and Jung Won Choi, and Ji Hoon Phi, and Seung-Ki Kim, and Dachling Pang, and Kyu-Chang Wang
February 1982, The Journal of experimental zoology,
Ji Yeoun Lee, and Saet Pyoul Kim, and Shin Won Kim, and Sung-Hye Park, and Jung Won Choi, and Ji Hoon Phi, and Seung-Ki Kim, and Dachling Pang, and Kyu-Chang Wang
January 1990, The Anatomical record,
Ji Yeoun Lee, and Saet Pyoul Kim, and Shin Won Kim, and Sung-Hye Park, and Jung Won Choi, and Ji Hoon Phi, and Seung-Ki Kim, and Dachling Pang, and Kyu-Chang Wang
June 2003, Birth defects research. Part A, Clinical and molecular teratology,
Ji Yeoun Lee, and Saet Pyoul Kim, and Shin Won Kim, and Sung-Hye Park, and Jung Won Choi, and Ji Hoon Phi, and Seung-Ki Kim, and Dachling Pang, and Kyu-Chang Wang
January 2009, The International journal of developmental biology,
Ji Yeoun Lee, and Saet Pyoul Kim, and Shin Won Kim, and Sung-Hye Park, and Jung Won Choi, and Ji Hoon Phi, and Seung-Ki Kim, and Dachling Pang, and Kyu-Chang Wang
April 2013, Neurosurgery,
Ji Yeoun Lee, and Saet Pyoul Kim, and Shin Won Kim, and Sung-Hye Park, and Jung Won Choi, and Ji Hoon Phi, and Seung-Ki Kim, and Dachling Pang, and Kyu-Chang Wang
November 2005, Journal of neurosurgery,
Ji Yeoun Lee, and Saet Pyoul Kim, and Shin Won Kim, and Sung-Hye Park, and Jung Won Choi, and Ji Hoon Phi, and Seung-Ki Kim, and Dachling Pang, and Kyu-Chang Wang
December 2002, Indian journal of pediatrics,
Ji Yeoun Lee, and Saet Pyoul Kim, and Shin Won Kim, and Sung-Hye Park, and Jung Won Choi, and Ji Hoon Phi, and Seung-Ki Kim, and Dachling Pang, and Kyu-Chang Wang
April 2005, Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia,
Copied contents to your clipboard!