Biomaterial Database

Evidence that secondary neurulation occurs autonomously in the chick embryo. 1982

R Costanzo, and R L Watterson, and G C Schoenwolf

Other investigations have demonstrated that pressure, exerted by fluid contained within the lumen of the closed neural tube, plays an important role in the morphogenesis of cranial regions of chick embryos. In this study, we investigated whether this pressure is involved also in the formation of the secondary portion of the neural tube--the portion formed by canalization of a solid mass of cells. To determine this, the posterior neuropore was prevented from closing (resulting in myeloschisis localized to he lumbosacral region) by removing the portion of the vitelline membrane covering the embryo, and reincubating for various periods. Secondary neurulation occurred normally in embryos exhibiting lumbosacral myeloschisis, demonstrating that this process occurs autonomously in chick embryos. Additional experimental studies are needed to ascertain what specific mechanisms cause the secondary portion of the neural tube to form.

UI	MeSH Term	Description	Entries
D008855	Microscopy, Electron, Scanning	Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.	Scanning Electron Microscopy,Electron Scanning Microscopy,Electron Microscopies, Scanning,Electron Microscopy, Scanning,Electron Scanning Microscopies,Microscopies, Electron Scanning,Microscopies, Scanning Electron,Microscopy, Electron Scanning,Microscopy, Scanning Electron,Scanning Electron Microscopies,Scanning Microscopies, Electron,Scanning Microscopy, Electron
D009432	Neural Crest	The two longitudinal ridges along the PRIMITIVE STREAK appearing near the end of GASTRULATION during development of nervous system (NEURULATION). The ridges are formed by folding of NEURAL PLATE. Between the ridges is a neural groove which deepens as the fold become elevated. When the folds meet at midline, the groove becomes a closed tube, the NEURAL TUBE.	Neural Crest Cells,Neural Fold,Neural Groove,Cell, Neural Crest,Cells, Neural Crest,Crest, Neural,Crests, Neural,Fold, Neural,Folds, Neural,Groove, Neural,Grooves, Neural,Neural Crest Cell,Neural Crests,Neural Folds,Neural Grooves
D002642	Chick Embryo	The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.	Embryo, Chick,Chick Embryos,Embryos, Chick
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014817	Vitelline Membrane	The plasma membrane of the egg.	Membrane, Vitelline,Membranes, Vitelline,Vitelline Membranes