Ortho- and para-selective ruthenium-catalyzed C(sp2)-H oxygenations of phenol derivatives. 2013

Weiping Liu, and Lutz Ackermann
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstr. 2, 37077 Göttingen, Germany.

Versatile ruthenium catalysts allowed for efficient direct oxygenations of aryl carbamates under remarkably mild reaction conditions. In addition to chelation-assisted C-H activation, the optimized ruthenium catalyst proved amenable to para-selective hydroxylations of anisoles without Lewis basic directing groups.

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