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We have investigated the effect of total denervation of the jejunoileum (JDNv) on stimulated release of peptide YY (PYY) and cholecystokinin-33/39 in five dogs prepared with chronic gastric and duodenal cannulas. JDNv was performed by stripping the adventitia from the superior mesenteric artery and vein, transecting the small bowel mesentery, and division (with reanastomosis) of the small bowel at the ligament of Treitz and ileocecal junctio. Introduodenal corn oil (3 ml/kg/hr) was given before JDNv and 1 and 2 months after JDNv. Intravenous bombesin (400 pmol/kg/hr) was given (on nonconsecutive days) before JDNv and 1 month after JDNv. Plasma PYY and cholecystokinin levels were measured by specific radioimmunoassay. Release of PYY was enhanced after JDNv. The integrated release of PYY (ng.[0 to 60 min]/ml) after intraduodenal corn oil was as follows: before JDNv, 4.1 +/- 1.2; 1 month after JDNv, 16.0 +/- 2.7; and 2 months after JDNv, 10.3 +/- 2.2. Similar results were noted with intravenous bombesin (3.7 +/- 0.9 [before JDNv] vs 12.0 +/- 0.7 [1 month after JDNv]). Corn oil-stimulated release of cholecystokinin was abolished after JDNv (before JDNv 2.2 +/- 1.1; 1 month after JDNv, 0.6 +/- 0.3; and 2 months after JDNv, 0.4 +/- 0.6). Basal plasma levels of PYY and cholecystokinin were not affected by JDNv. We conclude that JDNv enhances PYY and abolished cholecystokinin release, which provides evidence for different mechanisms of neural control.
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C M Townsend, and
T Uchida, and
G H Greeley, and
E Allen, and
J C Thompson
March 1989,
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B M Evers, and
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G H Greeley, and
E Allen, and
J C Thompson
August 1992,
Surgery, gynecology & obstetrics,
B M Evers, and
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G H Greeley, and
E Allen, and
J C Thompson
May 1991,
The Journal of surgical research,
B M Evers, and
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January 1988,
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B M Evers, and
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E Allen, and
J C Thompson
September 1988,
Surgery,
B M Evers, and
C M Townsend, and
T Uchida, and
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E Allen, and
J C Thompson
November 2001,
Digestive diseases and sciences,
B M Evers, and
C M Townsend, and
T Uchida, and
G H Greeley, and
E Allen, and
J C Thompson
July 1991,
Pancreas,
B M Evers, and
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J C Thompson
January 1988,
Gastroenterology,
B M Evers, and
C M Townsend, and
T Uchida, and
G H Greeley, and
E Allen, and
J C Thompson
April 1988,
The American journal of physiology,
B M Evers, and
C M Townsend, and
T Uchida, and
G H Greeley, and
E Allen, and
J C Thompson
February 1993,
Regulatory peptides,
