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The effects of natural peptide YY on pancreatic secretion under different stimulatory conditions and on fatty acid-induced cholecystokinin release were examined in five conscious dogs with pancreatic and gastric fistulas. Intravenous infusion of natural peptide YY at 1 and 0.2 microgram/kg/hr caused 60 and 40% inhibition of secretin- and cholecystokinin-stimulated secretion, respectively, and 40-50 and 20-40% inhibition of intraduodenal oleate stimulated secretion, respectively. A significant but transient decrease in the plasma cholecystokinin level was observed in response to peptide YY under oleate stimulation. The present study demonstrates that peptide YY has a potent inhibitory effect on both exogenously and endogenously stimulated pancreatic secretion and has a mild suppressive effect on fatty acid-induced cholecystokinin release suggesting that this peptide is an important colonic inhibitor of pancreatic secretion.
R Hosotani, and
K Inoue, and
M Kogire, and
K Tatemoto, and
V Mutt, and
T Suzuki, and
P L Rayford, and
T Tobe
July 1991,
Pancreas,
R Hosotani, and
K Inoue, and
M Kogire, and
K Tatemoto, and
V Mutt, and
T Suzuki, and
P L Rayford, and
T Tobe
December 1985,
Gastroenterology,
R Hosotani, and
K Inoue, and
M Kogire, and
K Tatemoto, and
V Mutt, and
T Suzuki, and
P L Rayford, and
T Tobe
January 1988,
Gastroenterology,
R Hosotani, and
K Inoue, and
M Kogire, and
K Tatemoto, and
V Mutt, and
T Suzuki, and
P L Rayford, and
T Tobe
April 1991,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
R Hosotani, and
K Inoue, and
M Kogire, and
K Tatemoto, and
V Mutt, and
T Suzuki, and
P L Rayford, and
T Tobe
January 1989,
Pancreas,
R Hosotani, and
K Inoue, and
M Kogire, and
K Tatemoto, and
V Mutt, and
T Suzuki, and
P L Rayford, and
T Tobe
March 1994,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
R Hosotani, and
K Inoue, and
M Kogire, and
K Tatemoto, and
V Mutt, and
T Suzuki, and
P L Rayford, and
T Tobe
January 1988,
Surgery, gynecology & obstetrics,
R Hosotani, and
K Inoue, and
M Kogire, and
K Tatemoto, and
V Mutt, and
T Suzuki, and
P L Rayford, and
T Tobe
February 1993,
Regulatory peptides,
R Hosotani, and
K Inoue, and
M Kogire, and
K Tatemoto, and
V Mutt, and
T Suzuki, and
P L Rayford, and
T Tobe
November 1983,
Gastroenterology,
R Hosotani, and
K Inoue, and
M Kogire, and
K Tatemoto, and
V Mutt, and
T Suzuki, and
P L Rayford, and
T Tobe
January 1988,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
