BIOMAT Database Logo BIOMAT Database Logo

Mycoplasma can enhance HIV replication in vitro: a possible cofactor responsible for the progression of AIDS. 1990

I H Chowdhury, and T Munakata, and Y Koyanagi, and S Kobayashi, and S Arai, and N Yamamoto
Department of Virology and Parasitology, Yamaguchi University School of Medicine, Japan.

Mycoplasma membrane protein (MMP) augmented HIV production from MOLT-4 cells chronically infected by HIV. A nearly 3-fold increase of HIV p24 antigen was detected in MMP-treated culture as compared to control culture at 100 micrograms/ml. MMP also augmented HIV production in different T cells chronically infected by HIV-1 and ARV-1. Kinetic experiment showed that HIV production was maximally elevated 24 hr after exposure to MMP. Similarly, MMP also augmented HIV-induced cell fusion and virus production in coculture. Hybridization experiment revealed that this augmentation was due to enhancement of HIV transcription.

UI MeSH Term Description Entries
D008565 Membrane Proteins Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors. Cell Membrane Protein,Cell Membrane Proteins,Cell Surface Protein,Cell Surface Proteins,Integral Membrane Proteins,Membrane-Associated Protein,Surface Protein,Surface Proteins,Integral Membrane Protein,Membrane Protein,Membrane-Associated Proteins,Membrane Associated Protein,Membrane Associated Proteins,Membrane Protein, Cell,Membrane Protein, Integral,Membrane Proteins, Integral,Protein, Cell Membrane,Protein, Cell Surface,Protein, Integral Membrane,Protein, Membrane,Protein, Membrane-Associated,Protein, Surface,Proteins, Cell Membrane,Proteins, Cell Surface,Proteins, Integral Membrane,Proteins, Membrane,Proteins, Membrane-Associated,Proteins, Surface,Surface Protein, Cell
D009174 Mycoplasma A genus of gram-negative, mostly facultatively anaerobic bacteria in the family MYCOPLASMATACEAE. The cells are bounded by a PLASMA MEMBRANE and lack a true CELL WALL. Its organisms are pathogens found on the MUCOUS MEMBRANES of humans, ANIMALS, and BIRDS. Eperythrozoon,Haemobartonella,Mycoplasma putrefaciens,PPLO,Pleuropneumonia-Like Organisms,Pleuropneumonia Like Organisms
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000911 Antibodies, Monoclonal Antibodies produced by a single clone of cells. Monoclonal Antibodies,Monoclonal Antibody,Antibody, Monoclonal
D013601 T-Lymphocytes Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen. T Cell,T Lymphocyte,T-Cells,Thymus-Dependent Lymphocytes,Cell, T,Cells, T,Lymphocyte, T,Lymphocyte, Thymus-Dependent,Lymphocytes, T,Lymphocytes, Thymus-Dependent,T Cells,T Lymphocytes,T-Cell,T-Lymphocyte,Thymus Dependent Lymphocytes,Thymus-Dependent Lymphocyte
D014409 Tumor Necrosis Factor-alpha Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS. Cachectin,TNF-alpha,Tumor Necrosis Factor Ligand Superfamily Member 2,Cachectin-Tumor Necrosis Factor,TNF Superfamily, Member 2,TNFalpha,Tumor Necrosis Factor,Cachectin Tumor Necrosis Factor,Tumor Necrosis Factor alpha
D014779 Virus Replication The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle. Viral Replication,Replication, Viral,Replication, Virus,Replications, Viral,Replications, Virus,Viral Replications,Virus Replications
D015488 HIV Antigens Antigens associated with specific proteins of the human adult T-cell immunodeficiency virus (HIV); also called HTLV-III-associated and lymphadenopathy-associated virus (LAV) antigens. AIDS Antigens,HIV-Associated Antigens,HTLV-III Antigens,HTLV-III-LAV Antigens,LAV Antigens,Lymphadenopathy-Associated Antigens,T-Lymphotropic Virus Type III Antigens, Human,HIV Associated Antigens,HTLV III Antigens,HTLV III LAV Antigens,Lymphadenopathy Associated Antigens,T Lymphotropic Virus Type III Antigens, Human,Antigens, AIDS,Antigens, HIV,Antigens, HIV Associated,Antigens, HIV-Associated,Antigens, HTLV III,Antigens, HTLV-III,Antigens, HTLV-III-LAV,Antigens, LAV,Antigens, Lymphadenopathy Associated,Antigens, Lymphadenopathy-Associated,Associated Antigens, HIV,Associated Antigens, Lymphadenopathy,III Antigens, HTLV
D015497 HIV-1 The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte. Human immunodeficiency virus 1,HIV-I,Human Immunodeficiency Virus Type 1,Immunodeficiency Virus Type 1, Human

Related Publications

I H Chowdhury, and T Munakata, and Y Koyanagi, and S Kobayashi, and S Arai, and N Yamamoto
Cytomegalovirus as a possible cofactor in HIV disease progression.
January 1991, Journal of acquired immune deficiency syndromes,
I H Chowdhury, and T Munakata, and Y Koyanagi, and S Kobayashi, and S Arai, and N Yamamoto
Alcohol consumption as a cofactor in the progression of HIV infection and AIDS.
January 1995, Alcohol (Fayetteville, N.Y.),
I H Chowdhury, and T Munakata, and Y Koyanagi, and S Kobayashi, and S Arai, and N Yamamoto
Cytomegalovirus seroconversion as a cofactor for progression to AIDS.
January 2001, AIDS (London, England),
I H Chowdhury, and T Munakata, and Y Koyanagi, and S Kobayashi, and S Arai, and N Yamamoto
Lymphocyte alloantigenic challenge as a potential cofactor in HIV infection and progression to AIDS.
January 1990, American journal of human biology : the official journal of the Human Biology Council,
I H Chowdhury, and T Munakata, and Y Koyanagi, and S Kobayashi, and S Arai, and N Yamamoto
CMV as a cofactor enhancing progression of AIDS.
April 2006, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology,
I H Chowdhury, and T Munakata, and Y Koyanagi, and S Kobayashi, and S Arai, and N Yamamoto
Looking for a 'superantigen' in AIDS: a possible role for Mycoplasma?
March 1993, Medical hypotheses,
I H Chowdhury, and T Munakata, and Y Koyanagi, and S Kobayashi, and S Arai, and N Yamamoto
Chlamydia trachomatis as a possible cofactor for Kaposi's sarcoma in AIDS.
January 1995, International journal of STD & AIDS,
I H Chowdhury, and T Munakata, and Y Koyanagi, and S Kobayashi, and S Arai, and N Yamamoto
Homologies between mycoplasma adhesion peptide, CD4 and class II MHC proteins: a possible mechanism for HIV-mycoplasma synergism in AIDS.
September 1991, Research in immunology,
I H Chowdhury, and T Munakata, and Y Koyanagi, and S Kobayashi, and S Arai, and N Yamamoto
Ethanol as a possible cofactor in the development of murine AIDS.
August 1995, Alcoholism, clinical and experimental research,
I H Chowdhury, and T Munakata, and Y Koyanagi, and S Kobayashi, and S Arai, and N Yamamoto
[Effect of GBV-C/HIV coinfection on HIV/AIDS disease progression and HIV replication].
January 2008, Bing du xue bao = Chinese journal of virology,
Copied contents to your clipboard!