Chlamydia trachomatis as a possible cofactor for Kaposi's sarcoma in AIDS. 1995

B S Peters, and B J Thomas, and C Yi, and E J Beck, and J Weber, and A J Pinching, and D Taylor-Robinson
Department of Genitourinary Medicine and Communicable Diseases, St Mary's Hospital Medical School, London, UK.

AIDS-associated Kaposi's sarcoma (KS) is much more frequent in patients acquiring HIV infection via the sexual route. Epidemiological studies have confirmed the likely involvement of a sexually acquired cofactor in the pathogenesis of this form of KS. We have formulated a set of postulates, epidemiological and experimental, to fit a single unifying hypothetical agent. Chlamydia trachomatis is one of 3 agents to fit the epidemiological criteria. Our data suggest a possible association between increased IgG serum antibody to C. trachomatis and the occurrence of KS. Conversely, higher titres of IgG serum antibody to C. pneumoniae were associated with the absence of KS. We feel that it is important to study further the relationship between C. trachomatis and KS.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D008297 Male Males
D002690 Chlamydia Infections Infections with bacteria of the genus CHLAMYDIA. Infections, Chlamydia,Chlamydia Infection,Infection, Chlamydia
D002692 Chlamydia trachomatis Type species of CHLAMYDIA causing a variety of ocular and urogenital diseases.
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000163 Acquired Immunodeficiency Syndrome An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993. AIDS,Immunodeficiency Syndrome, Acquired,Immunologic Deficiency Syndrome, Acquired,Acquired Immune Deficiency Syndrome,Acquired Immuno-Deficiency Syndrome,Acquired Immuno Deficiency Syndrome,Acquired Immuno-Deficiency Syndromes,Acquired Immunodeficiency Syndromes,Immuno-Deficiency Syndrome, Acquired,Immuno-Deficiency Syndromes, Acquired,Immunodeficiency Syndromes, Acquired,Syndrome, Acquired Immuno-Deficiency,Syndrome, Acquired Immunodeficiency,Syndromes, Acquired Immuno-Deficiency,Syndromes, Acquired Immunodeficiency
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000907 Antibodies, Bacterial Immunoglobulins produced in a response to BACTERIAL ANTIGENS. Bacterial Antibodies
D012514 Sarcoma, Kaposi A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause. Kaposi Sarcoma,Kaposi's Sarcoma,Multiple Idiopathic Pigmented Hemangiosarcoma,Kaposis Sarcoma,Sarcoma, Kaposi's

Related Publications

B S Peters, and B J Thomas, and C Yi, and E J Beck, and J Weber, and A J Pinching, and D Taylor-Robinson
February 2015, Oral oncology,
B S Peters, and B J Thomas, and C Yi, and E J Beck, and J Weber, and A J Pinching, and D Taylor-Robinson
December 1986, The Mount Sinai journal of medicine, New York,
B S Peters, and B J Thomas, and C Yi, and E J Beck, and J Weber, and A J Pinching, and D Taylor-Robinson
May 1992, Epidemiology (Cambridge, Mass.),
B S Peters, and B J Thomas, and C Yi, and E J Beck, and J Weber, and A J Pinching, and D Taylor-Robinson
January 2000, European journal of epidemiology,
B S Peters, and B J Thomas, and C Yi, and E J Beck, and J Weber, and A J Pinching, and D Taylor-Robinson
January 1989, Immunology series,
B S Peters, and B J Thomas, and C Yi, and E J Beck, and J Weber, and A J Pinching, and D Taylor-Robinson
October 1985, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
B S Peters, and B J Thomas, and C Yi, and E J Beck, and J Weber, and A J Pinching, and D Taylor-Robinson
September 1993, Nihon rinsho. Japanese journal of clinical medicine,
B S Peters, and B J Thomas, and C Yi, and E J Beck, and J Weber, and A J Pinching, and D Taylor-Robinson
January 1989, Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia,
B S Peters, and B J Thomas, and C Yi, and E J Beck, and J Weber, and A J Pinching, and D Taylor-Robinson
September 1985, Hiroshima journal of medical sciences,
B S Peters, and B J Thomas, and C Yi, and E J Beck, and J Weber, and A J Pinching, and D Taylor-Robinson
November 1995, AIDS (London, England),
Copied contents to your clipboard!