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Atomic force microscopy (AFM) was used to examine the morphology of live mammalian adherent and suspended cells. Time-lapse AFM was used to record the locomotion dynamics of MCF-7 and Neuro-2a cells. When a MCF-7 cell retracted, many small sawtooth-like filopodia formed and reorganized, and the thickness of cellular lamellipodium increased as the retraction progressed. In elongated Neuro-2a cells, the cytoskeleton reorganized from an irregular to a parallel, linear morphology. Suspended mammalian cells were immobilized by method combining polydimethylsiloxane-fabricated wells with poly-L-lysine electrostatic adsorption. In this way, the morphology of a single live lymphoma cell was imaged by AFM. The experimental results can improve our understanding of cell locomotion and may lead to improved immobilization strategies.
Mi Li, and
Lianqing Liu, and
Ning Xi, and
Yuechao Wang, and
Zaili Dong, and
Xiubin Xiao, and
Weijing Zhang
January 2017,
Biophysics and physicobiology,
Mi Li, and
Lianqing Liu, and
Ning Xi, and
Yuechao Wang, and
Zaili Dong, and
Xiubin Xiao, and
Weijing Zhang
July 2009,
Ultramicroscopy,
Mi Li, and
Lianqing Liu, and
Ning Xi, and
Yuechao Wang, and
Zaili Dong, and
Xiubin Xiao, and
Weijing Zhang
April 2004,
Colloids and surfaces. B, Biointerfaces,
Mi Li, and
Lianqing Liu, and
Ning Xi, and
Yuechao Wang, and
Zaili Dong, and
Xiubin Xiao, and
Weijing Zhang
January 2004,
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference,
Mi Li, and
Lianqing Liu, and
Ning Xi, and
Yuechao Wang, and
Zaili Dong, and
Xiubin Xiao, and
Weijing Zhang
March 2015,
Scientific reports,
Mi Li, and
Lianqing Liu, and
Ning Xi, and
Yuechao Wang, and
Zaili Dong, and
Xiubin Xiao, and
Weijing Zhang
June 2015,
Langmuir : the ACS journal of surfaces and colloids,
Mi Li, and
Lianqing Liu, and
Ning Xi, and
Yuechao Wang, and
Zaili Dong, and
Xiubin Xiao, and
Weijing Zhang
October 2010,
Cold Spring Harbor protocols,
Mi Li, and
Lianqing Liu, and
Ning Xi, and
Yuechao Wang, and
Zaili Dong, and
Xiubin Xiao, and
Weijing Zhang
November 2007,
Journal of molecular biology,
Mi Li, and
Lianqing Liu, and
Ning Xi, and
Yuechao Wang, and
Zaili Dong, and
Xiubin Xiao, and
Weijing Zhang
November 1993,
Chromosoma,
Mi Li, and
Lianqing Liu, and
Ning Xi, and
Yuechao Wang, and
Zaili Dong, and
Xiubin Xiao, and
Weijing Zhang
January 2003,
Methods in enzymology,
