-transparent.png){kind=logo}
In ocular cicatricial pemphigoid, the binding of circulating antibodies to conjunctiva is believed to initiate an antibody-mediated cytotoxic response that results in inflammation and tissue damage. To develop a model of antibody-mediated conjunctival inflammation, we examined the effect on conjunctiva of local or systemic administration of a murine monoclonal antibody against basement membrane of stratified squamous epithelium. Neonatal rabbits were given either a single subconjunctival or intraperitoneal injection of the antibody. Eyes were graded clinically for inflammation and conjunctival biopsies were performed. After subconjunctival injection, clinical and histologic inflammation as well as murine antibody and rabbit complement binding to conjunctival basement membrane were detected. With systemic administration there was post-injection clinical inflammation, and conjunctival basement membrane-bound murine antibody was detected. There was no difference observed in conjunctival mitotic rate or goblet cell frequency between treatment groups and controls, following either route of administration. We have created, therefore, a model for antibody-mediated conjunctivitis in rabbits by local or systemic administration of a monoclonal antibody against a component of stratified squamous epithelial basement membrane.
M I Roat, and
S P Alstadt, and
A B Carpenter, and
N SundarRaj, and
R A Thoft
January 1990,
Experimental pathology,
M I Roat, and
S P Alstadt, and
A B Carpenter, and
N SundarRaj, and
R A Thoft
September 1982,
Transplantation proceedings,
M I Roat, and
S P Alstadt, and
A B Carpenter, and
N SundarRaj, and
R A Thoft
December 1982,
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
M I Roat, and
S P Alstadt, and
A B Carpenter, and
N SundarRaj, and
R A Thoft
July 1978,
Journal of clinical pathology,
M I Roat, and
S P Alstadt, and
A B Carpenter, and
N SundarRaj, and
R A Thoft
June 1984,
Experientia,
M I Roat, and
S P Alstadt, and
A B Carpenter, and
N SundarRaj, and
R A Thoft
July 1990,
The American review of respiratory disease,
M I Roat, and
S P Alstadt, and
A B Carpenter, and
N SundarRaj, and
R A Thoft
April 1990,
Nihon Kyobu Shikkan Gakkai zasshi,
M I Roat, and
S P Alstadt, and
A B Carpenter, and
N SundarRaj, and
R A Thoft
February 1978,
The American journal of medicine,
M I Roat, and
S P Alstadt, and
A B Carpenter, and
N SundarRaj, and
R A Thoft
January 1985,
The Tohoku journal of experimental medicine,
M I Roat, and
S P Alstadt, and
A B Carpenter, and
N SundarRaj, and
R A Thoft
November 1990,
Agents and actions,
