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Four patients with rapidly progressive glomerulonephritis and pulmonary hemorrhage (Goodpasture's syndrome) induced by circulating anti-glomerular basement membrane (GBM) antibodies were treated with immunosuppressive agents and varying amounts of plasma exchange. All four patients showed progressive decreases in circulating anti-GBM antibody during therapy. Two patients with established renal failure before therapy showed no improvement in renal function but had a remission from pulmonary disease. In two other patients, renal failure developed early in the course of therapy and required maintenance hemodialysis. Later, their renal function improved coincident with a decrease in circulating anti-GBM antibody. Aggressive measures to reduce the levels of circulating anti-GBM antibody may have a salutory effect on the clinical course of the disease, particularly when undertaken early.
J P Johnson, and
W Whitman, and
W A Briggs, and
C B Wilson
April 1990,
Nihon Kyobu Shikkan Gakkai zasshi,
J P Johnson, and
W Whitman, and
W A Briggs, and
C B Wilson
May 1975,
British medical journal,
J P Johnson, and
W Whitman, and
W A Briggs, and
C B Wilson
May 1979,
Clinical and experimental immunology,
J P Johnson, and
W Whitman, and
W A Briggs, and
C B Wilson
March 1978,
Clinical nephrology,
J P Johnson, and
W Whitman, and
W A Briggs, and
C B Wilson
January 1990,
Investigative ophthalmology & visual science,
J P Johnson, and
W Whitman, and
W A Briggs, and
C B Wilson
June 1977,
The Medical journal of Australia,
J P Johnson, and
W Whitman, and
W A Briggs, and
C B Wilson
August 1989,
Ugeskrift for laeger,
J P Johnson, and
W Whitman, and
W A Briggs, and
C B Wilson
September 1979,
Medicine,
J P Johnson, and
W Whitman, and
W A Briggs, and
C B Wilson
January 1985,
Journal of immunopharmacology,
J P Johnson, and
W Whitman, and
W A Briggs, and
C B Wilson
November 1990,
Agents and actions,
