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We have detected a significant increase in the levels of pp60c-src kinase activity associated with the differentiation of myeloid cell lines HL-60 and U-937. The induction of pp60c-src kinase activity becomes apparent approximately 14 hr after the addition of phorbol 12-myristate 13-acetate and increases 20-fold by 72 hr. The enhanced kinase activity can be accounted for by elevated levels of c-src protein in the differentiated cells. When nonleukemic bone marrow cells were examined, myeloid progenitor cells exhibited a low level of pp60c-src kinase activity. As these cells are allowed to differentiate in culture, the resulting adherent monocytes are as high in pp60c-src kinase activity as HL-60 cells induced to differentiate into monocytes. A strong correlation is found between the levels of pp60c-src kinase activity and the degree of monocytic differentiation of the cells from patients with acute myeloid leukemia. Our findings suggest that the activation of pp60c-src kinase activity is a normal physiological event associated with myeloid differentiation.
C E Gee, and
J Griffin, and
L Sastre, and
L J Miller, and
T A Springer, and
H Piwnica-Worms, and
T M Roberts
May 1990,
International journal of cancer,
C E Gee, and
J Griffin, and
L Sastre, and
L J Miller, and
T A Springer, and
H Piwnica-Worms, and
T M Roberts
March 1989,
The Mount Sinai journal of medicine, New York,
C E Gee, and
J Griffin, and
L Sastre, and
L J Miller, and
T A Springer, and
H Piwnica-Worms, and
T M Roberts
May 1988,
Biochemical and biophysical research communications,
C E Gee, and
J Griffin, and
L Sastre, and
L J Miller, and
T A Springer, and
H Piwnica-Worms, and
T M Roberts
February 1991,
Journal of neuroscience research,
C E Gee, and
J Griffin, and
L Sastre, and
L J Miller, and
T A Springer, and
H Piwnica-Worms, and
T M Roberts
April 1987,
Proceedings of the National Academy of Sciences of the United States of America,
C E Gee, and
J Griffin, and
L Sastre, and
L J Miller, and
T A Springer, and
H Piwnica-Worms, and
T M Roberts
April 1993,
Oncogene,
C E Gee, and
J Griffin, and
L Sastre, and
L J Miller, and
T A Springer, and
H Piwnica-Worms, and
T M Roberts
July 1994,
Cellular and molecular biology (Noisy-le-Grand, France),
C E Gee, and
J Griffin, and
L Sastre, and
L J Miller, and
T A Springer, and
H Piwnica-Worms, and
T M Roberts
April 1986,
The EMBO journal,
C E Gee, and
J Griffin, and
L Sastre, and
L J Miller, and
T A Springer, and
H Piwnica-Worms, and
T M Roberts
July 1990,
Experimental cell research,
C E Gee, and
J Griffin, and
L Sastre, and
L J Miller, and
T A Springer, and
H Piwnica-Worms, and
T M Roberts
October 1993,
The Biochemical journal,
