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The histologic, morphometric, immunohistochemical, and ultrastructural study of a malignant Brenner tumor in a postmenopausal women presenting with vaginal bleeding is described. A comparison with transitional cell carcinomas is made, and the use of morphometry in grading the urothelial-like epithelium in malignant Brenner tumors is suggested. High preoperative urinary estrogen, low serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels and histologically confirmed atypical endometrial hyperplasia suggested a hyperestrogenism. The reduction in urinary estrogen and the increase in serum LH and FSH after tumor removal and the presence of aromatase activity detected in tumor microsomes confirmed that the tumor was synthesizing estrogen. Estrogen receptors were undetectable both by biochemical and histochemical analysis in the tumor.
C A Seldenrijk, and
A P Willig, and
J P Baak, and
R Kühnel, and
B R Rao, and
C W Burger, and
J J van der Harten, and
G H Dijkhuizen, and
C J Meijer
August 1989,
Human pathology,
C A Seldenrijk, and
A P Willig, and
J P Baak, and
R Kühnel, and
B R Rao, and
C W Burger, and
J J van der Harten, and
G H Dijkhuizen, and
C J Meijer
January 1981,
Human pathology,
C A Seldenrijk, and
A P Willig, and
J P Baak, and
R Kühnel, and
B R Rao, and
C W Burger, and
J J van der Harten, and
G H Dijkhuizen, and
C J Meijer
December 1965,
Nihon Sanka Fujinka Gakkai zasshi,
C A Seldenrijk, and
A P Willig, and
J P Baak, and
R Kühnel, and
B R Rao, and
C W Burger, and
J J van der Harten, and
G H Dijkhuizen, and
C J Meijer
October 1972,
Cancer,
C A Seldenrijk, and
A P Willig, and
J P Baak, and
R Kühnel, and
B R Rao, and
C W Burger, and
J J van der Harten, and
G H Dijkhuizen, and
C J Meijer
December 1992,
Zhonghua bing li xue za zhi = Chinese journal of pathology,
C A Seldenrijk, and
A P Willig, and
J P Baak, and
R Kühnel, and
B R Rao, and
C W Burger, and
J J van der Harten, and
G H Dijkhuizen, and
C J Meijer
December 2014,
Human pathology,
C A Seldenrijk, and
A P Willig, and
J P Baak, and
R Kühnel, and
B R Rao, and
C W Burger, and
J J van der Harten, and
G H Dijkhuizen, and
C J Meijer
July 1984,
Cancer,
C A Seldenrijk, and
A P Willig, and
J P Baak, and
R Kühnel, and
B R Rao, and
C W Burger, and
J J van der Harten, and
G H Dijkhuizen, and
C J Meijer
June 1986,
Chinese medical journal,
C A Seldenrijk, and
A P Willig, and
J P Baak, and
R Kühnel, and
B R Rao, and
C W Burger, and
J J van der Harten, and
G H Dijkhuizen, and
C J Meijer
April 1985,
Cancer,
C A Seldenrijk, and
A P Willig, and
J P Baak, and
R Kühnel, and
B R Rao, and
C W Burger, and
J J van der Harten, and
G H Dijkhuizen, and
C J Meijer
November 2000,
Journal of cutaneous pathology,
