Brenner tumor of the ovary: a correlative histologic, histochemical, immunohistochemical, and ultrastructural investigation. 1989

D Santini, and M C Gelli, and G Mazzoleni, and M Ricci, and B Severi, and G Pasquinelli, and G Pelusi, and G Martinelli
Istituto di Anatomia Patologica, University of Bologna, Italy.

The histologic, histochemical, immunohistochemical, and ultrastructural features of Brenner tumor (BT) were studied. BT was compared with transitional bladder cells, and close similarities between the two tissues were identified. Abundant glycogen in all cellular layers, an alcianophilic/sialomucinic surface mucous coat, and argyrophilic cells characterized both BT and bladder epithelium. Immunohistochemically, chromogranin and neuron-specific enolase reactivity was observed in all cases examined. An additional relevant finding was the presence of serotonin-storing cells in both BT and urothelium. Moreover, carcinoembryonic antigen, epithelial membrane antigen, and keratin reaction were found in BT and urothelium, indicating an additional antigenic similarity. Additionally, malignant Brenner tumor was ultrastructurally found to share many common features with the bladder tissue. The distinct histochemical, ultrastructural, and antigenic pattern of BT, primarily of the transitional type, is emphasized.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008854 Microscopy, Electron Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen. Electron Microscopy
D010051 Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. Cancer of Ovary,Ovarian Cancer,Cancer of the Ovary,Neoplasms, Ovarian,Ovary Cancer,Ovary Neoplasms,Cancer, Ovarian,Cancer, Ovary,Cancers, Ovarian,Cancers, Ovary,Neoplasm, Ovarian,Neoplasm, Ovary,Neoplasms, Ovary,Ovarian Cancers,Ovarian Neoplasm,Ovary Cancers,Ovary Neoplasm
D001948 Brenner Tumor A smooth, solid or cystic fibroepithelial (FIBROEPITHELIAL NEOPLASMS) tumor, usually found in the OVARIES but can also be found in the adnexal region and the KIDNEYS. It consists of a fibrous stroma with nests of epithelial cells that sometimes resemble the transitional cells lining the urinary bladder. Brenner tumors generally are benign and asymptomatic. Malignant Brenner tumors have been reported. Benign Brenner Tumor,Brenner Tumor of Ovary,Malignant Brenner Tumor,Ovarian Brenner Tumor,Proliferative Brenner Tumor,Brenner Tumor, Benign,Brenner Tumor, Malignant,Brenner Tumor, Proliferative,Ovary Brenner Tumor
D002272 Carcinoembryonic Antigen A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment. Antigens, CD66e,CD66e Antigen,Antigen, CD66e,Antigen, Carcinoembryonic,CD66e Antigens
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

D Santini, and M C Gelli, and G Mazzoleni, and M Ricci, and B Severi, and G Pasquinelli, and G Pelusi, and G Martinelli
August 1986, Cancer,
D Santini, and M C Gelli, and G Mazzoleni, and M Ricci, and B Severi, and G Pasquinelli, and G Pelusi, and G Martinelli
October 1972, Cancer,
D Santini, and M C Gelli, and G Mazzoleni, and M Ricci, and B Severi, and G Pasquinelli, and G Pelusi, and G Martinelli
January 1993, Virchows Archiv. A, Pathological anatomy and histopathology,
D Santini, and M C Gelli, and G Mazzoleni, and M Ricci, and B Severi, and G Pasquinelli, and G Pelusi, and G Martinelli
January 2000, Ultrastructural pathology,
D Santini, and M C Gelli, and G Mazzoleni, and M Ricci, and B Severi, and G Pasquinelli, and G Pelusi, and G Martinelli
January 2006, Ultrastructural pathology,
D Santini, and M C Gelli, and G Mazzoleni, and M Ricci, and B Severi, and G Pasquinelli, and G Pelusi, and G Martinelli
December 1993, Histopathology,
D Santini, and M C Gelli, and G Mazzoleni, and M Ricci, and B Severi, and G Pasquinelli, and G Pelusi, and G Martinelli
December 1992, Zhonghua bing li xue za zhi = Chinese journal of pathology,
D Santini, and M C Gelli, and G Mazzoleni, and M Ricci, and B Severi, and G Pasquinelli, and G Pelusi, and G Martinelli
October 2014, Journal of ovarian research,
D Santini, and M C Gelli, and G Mazzoleni, and M Ricci, and B Severi, and G Pasquinelli, and G Pelusi, and G Martinelli
November 1985, Archives of pathology & laboratory medicine,
D Santini, and M C Gelli, and G Mazzoleni, and M Ricci, and B Severi, and G Pasquinelli, and G Pelusi, and G Martinelli
January 1994, Revista chilena de obstetricia y ginecologia,
Copied contents to your clipboard!