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Through gene transfection studies, we have discovered that the forced expression of a foreign type II epidermal keratin in fibroblasts can trigger the expression of an endogenous type I epidermal keratin. Both the transfected and the induced proteins participate in the formation of filamentous structures. Interestingly, this regulation appears to be unidirectional: the expression of a transfected type I keratin does not induce type II expression. Rather, nonfilamentous aggregates of type I protein accumulate in the cytoplasm. In contrast, simple epithelial cells transfected with either a type I or a type II epidermal keratin gene do not respond by inducing the expression of a host epidermal keratin. In this case, the foreign protein is incorporated into the endogenous keratin network. These results suggest the possibility that type I keratin expression may be dependent on the accumulation of unpolymerized type II keratin.
G J Giudice, and
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G J Giudice, and
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G J Giudice, and
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G J Giudice, and
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G J Giudice, and
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G J Giudice, and
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G J Giudice, and
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G J Giudice, and
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Current topics in developmental biology,
