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The mechanisms controlling vagally induced 5-HT and SP release into the jejunal lumen were studied in the cat. In control animals, electrical vagal nerve stimulation doubled the rate of endoluminal secretion of 5-HT and SP. Propranolol pretreatment did not alter luminal secretion of these hormones. Atropine suppressed motor function and induced dose-related inhibition of vagal release of endoluminal 5-HT, but not of SP; the response to hexamethonium pretreatment was similar to that of atropine. In contrast, superior cervical ganglionectomy did not alter stimulated endoluminal 5-HT release but it completely abolished release into the portal vein. The portal 5-HT release was not affected by ganglionic blockade. The data suggest that vagally mediated 5-HT release into the lumen and the portal circulation are mediated by different neural mechanisms, the former cholinergic, the latter presumably adrenergic; and release of feline 5-HT and SP are independent, suggesting two intestinal sources, the EC cell for 5-HT and peptidergic neurons for SP.
K Gronstad, and
A Dahlstrom, and
L Florence, and
M J Zinner, and
J Ahlman, and
B M Jaffe
March 1985,
Scandinavian journal of gastroenterology,
K Gronstad, and
A Dahlstrom, and
L Florence, and
M J Zinner, and
J Ahlman, and
B M Jaffe
December 1989,
European journal of pharmacology,
K Gronstad, and
A Dahlstrom, and
L Florence, and
M J Zinner, and
J Ahlman, and
B M Jaffe
August 1983,
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K Gronstad, and
A Dahlstrom, and
L Florence, and
M J Zinner, and
J Ahlman, and
B M Jaffe
November 1994,
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K Gronstad, and
A Dahlstrom, and
L Florence, and
M J Zinner, and
J Ahlman, and
B M Jaffe
February 1988,
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K Gronstad, and
A Dahlstrom, and
L Florence, and
M J Zinner, and
J Ahlman, and
B M Jaffe
September 1986,
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K Gronstad, and
A Dahlstrom, and
L Florence, and
M J Zinner, and
J Ahlman, and
B M Jaffe
December 1982,
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K Gronstad, and
A Dahlstrom, and
L Florence, and
M J Zinner, and
J Ahlman, and
B M Jaffe
December 1982,
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K Gronstad, and
A Dahlstrom, and
L Florence, and
M J Zinner, and
J Ahlman, and
B M Jaffe
March 1987,
Digestive diseases and sciences,
K Gronstad, and
A Dahlstrom, and
L Florence, and
M J Zinner, and
J Ahlman, and
B M Jaffe
January 1990,
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