Associations of serum 25-hydroxyvitamin D3 levels with visceral adipose tissue in Chinese men with normal glucose tolerance. 2014

Yaping Hao, and Xiaojing Ma, and Yun Shen, and Jie Ni, and Yuqi Luo, and Yunfeng Xiao, and Yuqian Bao, and Weiping Jia
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.

OBJECTIVE Decreased serum vitamin D level is a common observation in obese adults. Since no Chinese population-based study has yet evaluated the relationship between serum vitamin D levels and the accurate adiposity variables, this study investigated the association of serum vitamin D (assessed by 25-hydroxyvitamin D3 [25(OH)D3]) levels with precise body fat content and distribution in a cohort of Chinese men. METHODS Serum samples were collected from a total of 567 men with normal glucose tolerance (NGT) for assessment by electrochemiluminescence immunoassay to measure 25(OH)D3 levels. In addition, each participant underwent bioelectrical impedance analysis to quantify total body fat and magnetic resonance imaging to measure visceral fat area (VFA) and subcutaneous fat area (SFA). RESULTS Overweight/obese (BMI ≥25 kg/m(2)) subjects had significantly lower serum 25(OH)D3 levels than non-overweight/non-obese (BMI <25 kg/m(2)) subjects (P  =  0.029). Greater fat mass and VFA were accompanied by a downward trend in serum 25(OH)D3 levels (P for trend <0.01). Among overweight/obese subjects, those with body fat percent ≥25% also had significantly lower serum 25(OH)D3 levels (P <0.05). Moreover, participants with VFA ≥80 cm(2) had significantly lower serum 25(OH)D3 (P <0.05), regardless of BMI value. VFA was independently correlated with serum 25(OH)D3 levels (β  =  -0.023, P <0.001), even after adjustments for confounding factors. In addition, serum 25(OH)D3 levels were found to decrease by 0.26 ng/mL per 10 cm(2) increment of VFA. CONCLUSIONS Serum 25(OH)D3 levels were inversely associated with VFA in Chinese men with NGT.

UI MeSH Term Description Entries
D007118 Immunoassay A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance. Immunochromatographic Assay,Assay, Immunochromatographic,Assays, Immunochromatographic,Immunoassays,Immunochromatographic Assays
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D002112 Calcifediol The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties. 25-Hydroxycholecalciferol,25-Hydroxyvitamin D 3,25-Hydroxycholecalciferol Monohydrate,25-Hydroxyvitamin D3,Calcidiol,Calcifediol Anhydrous,Calcifediol, (3 alpha,5Z,7E)-Isomer,Calcifediol, (3 beta,5E,7E)-Isomer,Calderol,Dedrogyl,Hidroferol,25 Hydroxycholecalciferol,25 Hydroxycholecalciferol Monohydrate,25 Hydroxyvitamin D 3,25 Hydroxyvitamin D3,Anhydrous, Calcifediol,Monohydrate, 25-Hydroxycholecalciferol
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000886 Anthropometry The technique that deals with the measurement of the size, weight, and proportions of the human or other primate body.
D017097 Electric Impedance The resistance to the flow of either alternating or direct electrical current. Bioelectrical Impedance,Electric Resistance,Impedance,Ohmic Resistance,Biolectric Impedance,Electrical Impedance,Electrical Resistance,Impedance, Bioelectrical,Impedance, Biolectric,Impedance, Electric,Impedance, Electrical,Ohmic Resistances,Resistance, Electric,Resistance, Electrical,Resistance, Ohmic,Resistances, Ohmic
D044466 Asian People Persons having origins in any of the Asian racial groups of the Far East, Southeast Asia, or the Indian subcontinent including, for example, Cambodia, China, India, Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, and Vietnam. Note that OMB category ASIAN is available for United States population groups. Race and ethnicity terms, as used in the federal government, are self-identified social construct and may include terms outdated and offensive in MeSH to assist users who are interested in retrieving comprehensive search results for studies such as in longitudinal studies. Asian Continental Ancestry Group,Asian Person,Asiatic Race,Mongoloid Race,Asian Peoples,Asian Persons,Asiatic Races,Mongoloid Races,People, Asian,Person, Asian,Race, Asiatic,Race, Mongoloid
D050152 Intra-Abdominal Fat Fatty tissue inside the ABDOMINAL CAVITY, including visceral fat and retroperitoneal fat. It is the most metabolically active fat in the body and easily accessible for LIPOLYSIS. Increased visceral fat is associated with metabolic complications of OBESITY. Abdominal Visceral Fat,Fat, Intra-Abdominal,Intra-Abdominal Adipose Tissue,Retroperitoneal Adipose Tissue,Retroperitoneal Fat,Visceral Adipose Tissue,Visceral Fat,Abdominal Visceral Fats,Adipose Tissue, Intra-Abdominal,Adipose Tissue, Retroperitoneal,Adipose Tissue, Visceral,Fat, Abdominal Visceral,Fat, Intra Abdominal,Fat, Retroperitoneal,Fat, Visceral,Fats, Abdominal Visceral,Fats, Intra-Abdominal,Fats, Retroperitoneal,Fats, Visceral,Intra Abdominal Adipose Tissue,Intra Abdominal Fat,Intra-Abdominal Fats,Retroperitoneal Fats,Visceral Fats

Related Publications

Yaping Hao, and Xiaojing Ma, and Yun Shen, and Jie Ni, and Yuqi Luo, and Yunfeng Xiao, and Yuqian Bao, and Weiping Jia
March 1995, Diabetes research and clinical practice,
Yaping Hao, and Xiaojing Ma, and Yun Shen, and Jie Ni, and Yuqi Luo, and Yunfeng Xiao, and Yuqian Bao, and Weiping Jia
October 1979, Vnitrni lekarstvi,
Yaping Hao, and Xiaojing Ma, and Yun Shen, and Jie Ni, and Yuqi Luo, and Yunfeng Xiao, and Yuqian Bao, and Weiping Jia
August 1977, Acta hepato-gastroenterologica,
Yaping Hao, and Xiaojing Ma, and Yun Shen, and Jie Ni, and Yuqi Luo, and Yunfeng Xiao, and Yuqian Bao, and Weiping Jia
May 1979, The Journal of clinical endocrinology and metabolism,
Yaping Hao, and Xiaojing Ma, and Yun Shen, and Jie Ni, and Yuqi Luo, and Yunfeng Xiao, and Yuqian Bao, and Weiping Jia
July 1992, Diabetes,
Yaping Hao, and Xiaojing Ma, and Yun Shen, and Jie Ni, and Yuqi Luo, and Yunfeng Xiao, and Yuqian Bao, and Weiping Jia
January 2015, Diabetology & metabolic syndrome,
Yaping Hao, and Xiaojing Ma, and Yun Shen, and Jie Ni, and Yuqi Luo, and Yunfeng Xiao, and Yuqian Bao, and Weiping Jia
January 2016, International journal of pediatric otorhinolaryngology,
Yaping Hao, and Xiaojing Ma, and Yun Shen, and Jie Ni, and Yuqi Luo, and Yunfeng Xiao, and Yuqian Bao, and Weiping Jia
January 1999, Annals of clinical biochemistry,
Yaping Hao, and Xiaojing Ma, and Yun Shen, and Jie Ni, and Yuqi Luo, and Yunfeng Xiao, and Yuqian Bao, and Weiping Jia
March 1995, Diabetes care,
Yaping Hao, and Xiaojing Ma, and Yun Shen, and Jie Ni, and Yuqi Luo, and Yunfeng Xiao, and Yuqian Bao, and Weiping Jia
January 2022, Journal of affective disorders,
Copied contents to your clipboard!