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Wound bed preparation 2014 update: management of critical colonization with a gentian violet and methylene blue absorbent antibacterial dressing and elevated levels of matrix metalloproteases with an ovine collagen extracellular matrix dressing. 2014

R Gary Sibbald, and Liza G Ovington, and Elizabeth A Ayello, and Laurie Goodman, and James A Elliott
R. Gary Sibbald, BSc, MD, MEd, FRCPC(Med Derm), MACP, FAAD, MAPWCA, is Professor of Public Health and Medicine, University of Toronto, Ontario, Canada; Director, International Interprofessional Wound Care Course & Masters of Science in Community Health (Prevention & Wound Care), Dalla Lana School of Public Health, University of Toronto; Past President, World Union of Wound Healing Societies; Course Coordinator, International Interprofessional Wound Care Course at New York University Medical Center, and Clinical Editor, Advances in Skin & Wound Care, Philadelphia, Pennsylvania. Liza G. Ovington, PhD, FACCWS, is Director, Medical Operations, Global Surgery Group, Ethicon Inc, Somerville, New Jersey. Elizabeth A. Ayello, PhD, RN, ACNS-BC, CWON, ETN, MAPCWA, FAAN, is Faculty, Excelsior College of Nursing, Albany, New York; Senior Advisor, The John A. Hartford Institute for Geriatric Nursing, New York; President, Ayello, Harris & Associates, New York; Course Coordinator, International Interprofessional Wound Care Course at New York University Medical Center; and Clinical Editor, Advances in Skin & Wound Care, Philadelphia, Pennsylvania. Laurie Goodman, MHScN, BA, RN, IIWCC (Toronto), is an Advanced Practice Nurse and Wound Educator, Toronto Regional Wound Healing Clinics, Ontario, Canada. James A. Elliott, MMsc, BSc, is an independent researcher, Toronto, Canada. Dr Sibbald has disclosed that his employer, the University of Toronto, is the recipient of an unconditional educational grant from Hollister Inc, research grants from Healthpoint Biotherapeutics, Systagenix, and Exiton, and was the recipient of research grants from the Government of Ontario, 3M, BSN, CIDA, Coloplast, Covidien, Gaymar, KCI, Johnson & Johnson, Registered Nurses Association of Ontario, Mölnlycke, Hollister Limited, Valeant, Shire, Galderma, Leo, Stiefel, Abbott, and Mississauga Halton Community Care Access Center; he is a board member of 3M, BSN, Coloplast, Covidien, Gaymar, KCI, Systagenix, Möln

Wound bed preparation (WBP) is a paradigm for holistic patient care that includes treatment of the cause along with patient-centered concerns before optimizing the components of local wound care (debridement, infection/inflammation, moisture balance, and, when required, the edge effect). This review incorporates a methylene blue and gentian violet bound foam dressing for critical colonization and an ovine collagen extracellular matrix dressing for reduction of elevated levels of matrix metalloproteases into the WBP paradigm.

UI MeSH Term Description Entries
D008297 Male Males
D008751 Methylene Blue A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN. Methylthionine Chloride,Swiss Blue,Basic Blue 9,Chromosmon,Methylene Blue N,Methylthioninium Chloride,Urolene Blue,Blue 9, Basic,Blue N, Methylene,Blue, Methylene,Blue, Swiss,Blue, Urolene
D009779 Occlusive Dressings Material, usually gauze or absorbent cotton, used to cover and protect wounds, to seal them from contact with air or bacteria. (From Dorland, 27th ed) Bandages, Occlusive,Dressings, Occlusive,Dressings, Spray-On,Bandage, Occlusive,Dressing, Occlusive,Dressing, Spray-On,Dressings, Spray On,Occlusive Bandage,Occlusive Bandages,Occlusive Dressing,Spray-On Dressing,Spray-On Dressings
D003131 Combined Modality Therapy The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used. Multimodal Treatment,Therapy, Combined Modality,Combined Modality Therapies,Modality Therapies, Combined,Modality Therapy, Combined,Multimodal Treatments,Therapies, Combined Modality,Treatment, Multimodal,Treatments, Multimodal
D003646 Debridement The removal of foreign material and devitalized or contaminated tissue from or adjacent to a traumatic or infected lesion until surrounding healthy tissue is exposed. (Dorland, 27th ed) Debridements
D005109 Extracellular Matrix A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere. Matrix, Extracellular,Extracellular Matrices,Matrices, Extracellular
D005260 Female Females
D005840 Gentian Violet A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties. Crystal Violet,Methyl Violet,Methylrosaniline Chloride,C.I. 42555,Gentiaanviolet FNA,Hexamethylpararosaniline Chloride,Kristallviolett-Lösung,Vigencial,Chloride, Hexamethylpararosaniline,Chloride, Methylrosaniline,FNA, Gentiaanviolet,Kristallviolett Lösung,Violet, Crystal,Violet, Gentian,Violet, Methyl
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

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