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Anti-type I and type III collagen polyclonal antibodies and anti-type III collagen monoclonal antibodies were produced using type I and type III collagen extracted from the human placenta. An indirect immunofluorescence technique using these antibodies showed the same distribution of type III as well as type I collagen in the entire dermis of the normal human skin in nearly identical patterns. Previous immunofluorescent study indicated that type III collagen is present predominantly in the papillary dermis. However, our observation that monoclonal antibody recognizing the helical portion of type III collagen reacted with the entire thickness of the dermis which suggested the presence of type I and III collagen in close proximity in the whole thickness of normal human dermis.
K Fukai, and
M Ishii, and
M Chanoki, and
H Kobayashi, and
T Hamada, and
Y Muragaki, and
A Ooshima
January 1989,
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K Fukai, and
M Ishii, and
M Chanoki, and
H Kobayashi, and
T Hamada, and
Y Muragaki, and
A Ooshima
March 1982,
The British journal of dermatology,
K Fukai, and
M Ishii, and
M Chanoki, and
H Kobayashi, and
T Hamada, and
Y Muragaki, and
A Ooshima
February 1992,
Matrix (Stuttgart, Germany),
K Fukai, and
M Ishii, and
M Chanoki, and
H Kobayashi, and
T Hamada, and
Y Muragaki, and
A Ooshima
December 1981,
Proceedings of the National Academy of Sciences of the United States of America,
K Fukai, and
M Ishii, and
M Chanoki, and
H Kobayashi, and
T Hamada, and
Y Muragaki, and
A Ooshima
November 1982,
Collagen and related research,
K Fukai, and
M Ishii, and
M Chanoki, and
H Kobayashi, and
T Hamada, and
Y Muragaki, and
A Ooshima
December 1976,
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K Fukai, and
M Ishii, and
M Chanoki, and
H Kobayashi, and
T Hamada, and
Y Muragaki, and
A Ooshima
April 1994,
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K Fukai, and
M Ishii, and
M Chanoki, and
H Kobayashi, and
T Hamada, and
Y Muragaki, and
A Ooshima
December 1996,
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K Fukai, and
M Ishii, and
M Chanoki, and
H Kobayashi, and
T Hamada, and
Y Muragaki, and
A Ooshima
January 1989,
Pathology and immunopathology research,
K Fukai, and
M Ishii, and
M Chanoki, and
H Kobayashi, and
T Hamada, and
Y Muragaki, and
A Ooshima
July 1981,
Acta pathologica japonica,
