OBJECTIVE The bonding interface of glass ceramics and resin luting cements plays an important role in the long-term durability of ceramic restorations. The purpose of this systematic review is to discuss the various factors involved with the bond between glass ceramics and resin luting cements. METHODS An electronic Pubmed, Medline and Embase search was conducted to obtain laboratory studies on resin-ceramic bonding published in English and Chinese between 1972 and 2012. CONCLUSIONS Eighty-three articles were included in this review. Various factors that have a possible impact on the bond between glass ceramics and resin cements were discussed, including ceramic type, ceramic crystal structure, resin luting cements, light curing, surface treatments, and laboratory test methodology. CONCLUSIONS Resin-ceramic bonding has been improved substantially in the past few years. Hydrofluoric acid (HF) etching followed by silanizaiton has become the most widely accepted surface treatment for glass ceramics. However, further studies need to be undertaken to improve surface preparations without HF because of its toxicity. Laboratory test methods are also required to better simulate the actual oral environment for more clinically compatible testing.