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A 28-year-old man with a large abdominal mass was found to have a tumor involving the peritoneum that had no other apparent primary origin. By light microscopy, the histologic pattern of the tumor was that of a small-cell epithelial neoplasm. Electron-microscopic examination demonstrated desmosomes and paranuclear aggregates of intermediate filaments. Immunohistochemical studies revealed reactivity for keratin, desmin, and vimentin. The globoid staining observed for the last two markers correlated with the paranuclear concentration of intermediate filaments observed by electron microscopy. We believe this case represents an unusual small-cell epithelial tumor, expressing mesenchymal-type intermediate filaments, that should be distinguished from other small-cell neoplasms.
N G Ordóñez, and
R Zirkin, and
R E Bloom
October 1991,
American journal of clinical pathology,
N G Ordóñez, and
R Zirkin, and
R E Bloom
January 1987,
Current topics in pathology. Ergebnisse der Pathologie,
N G Ordóñez, and
R Zirkin, and
R E Bloom
January 1985,
Laboratory investigation; a journal of technical methods and pathology,
N G Ordóñez, and
R Zirkin, and
R E Bloom
November 1991,
Der Pathologe,
N G Ordóñez, and
R Zirkin, and
R E Bloom
February 1986,
Journal of cutaneous pathology,
N G Ordóñez, and
R Zirkin, and
R E Bloom
January 1982,
Pathology, research and practice,
N G Ordóñez, and
R Zirkin, and
R E Bloom
October 2019,
Essays in biochemistry,
N G Ordóñez, and
R Zirkin, and
R E Bloom
January 1983,
Virchows Archiv. A, Pathological anatomy and histopathology,
N G Ordóñez, and
R Zirkin, and
R E Bloom
April 1984,
The Journal of cell biology,
N G Ordóñez, and
R Zirkin, and
R E Bloom
January 1992,
Cell motility and the cytoskeleton,
