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Three new cucurbitane triterpenoids from Hemsleya penxianensis and their cytotoxic activities. 2014
Xiaoting Xu, and
Hong Bai, and
Ling Zhou, and
Zhipeng Deng, and
Hao Zhong, and
Zhongyu Wu, and
Qingqiang Yao
Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China; School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China.
Two new cucurbitane glycosides, hemslepenside A (1) and 16,25-O-diacetyl-cucurbitacin F-2-O-β-d-glucopyranoside (3), one new cucurbitacin, 16-O-acetyl-cucurbitacin F (2), along with three known cucurbitane compounds, were isolated from the roots of Hemsleya penxianensis. The structures of 1-6 were established on the basis of extensive spectroscopic and chemical methods. The isolated compounds were evaluated for their cytotoxic activities against different three human cancer cell lines, with IC50 values in the low microgram range.
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