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Cucurbitane triterpenes from Hemsleya chinensis tubers and their anti-inflammatory activities. 2023
Feihe Lian, and
Jun Chi, and
Qionglin Meng, and
Qingxia Li, and
Anying Chen, and
Zhimin Wang, and
Liping Dai
Henan University of Chinese Medicine, Zhengzhou, Henan 450046, PR China; Engineering Technology Research Center for Comprehensive Development and Utilization of Authentic Medicinal Materials in Henan Province, Zhengzhou, Henan 450046, PR China.
Six new cucurbitane-type triterpenes, hemchinins A-F (1-6), together with thirteen known ones (7-19) were isolated from ethyl acetate extraction of Hemsleya chinensis tubers. Compounds 1-2 were a group of cucurbitane triterpenes possessing an infrequent pentacyclic framework. Their structures were established by comprehensive UV, IR, HRMS, 1D/2D NMR, and ECD analyses. Bioassay results showed that most isolated compounds exhibited anti-inflammatory actions, in which compounds 13 and 15 exhibited stronger activities at 6.25 μM, with NO inhibition rates of 49.00 ± 0.05% and 48.40 ± 0.10%, respectively.
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