-transparent.png){kind=logo}
Ten histological criteria were evaluated semiquantitatively in the liver biopsies of 60 patients with rheumatoid arthritis (RA) before initiation of methotrexate (MTX) and were compared with 40 biopsies taken during MTX treatment (mean cumulative dose 1.322 mg). Mesenchymal changes (Kupffer cell proliferation, portal tract infiltration) and parenchymal alterations (nuclear variability, ballooning, fatty infiltration) were very common without statistically significant difference between the 2 groups. Slight periportal and/or portal fibrosis was present in 25% of patients without statistical difference between groups. Central fibrosis occurred in 13.5-12.5%. We conclude that liver abnormalities in RA are not related to MTX treatment.
R Rau, and
T Karger, and
G Herborn, and
H Frenzel
January 1996,
The Journal of pediatrics,
R Rau, and
T Karger, and
G Herborn, and
H Frenzel
December 1985,
The Journal of rheumatology. Supplement,
R Rau, and
T Karger, and
G Herborn, and
H Frenzel
March 1995,
Arthritis and rheumatism,
R Rau, and
T Karger, and
G Herborn, and
H Frenzel
May 1990,
The Journal of rheumatology. Supplement,
R Rau, and
T Karger, and
G Herborn, and
H Frenzel
December 1987,
Nederlands tijdschrift voor geneeskunde,
R Rau, and
T Karger, and
G Herborn, and
H Frenzel
April 1991,
The Journal of pediatrics,
R Rau, and
T Karger, and
G Herborn, and
H Frenzel
January 2020,
Current rheumatology reviews,
R Rau, and
T Karger, and
G Herborn, and
H Frenzel
May 2000,
The Journal of rheumatology,
R Rau, and
T Karger, and
G Herborn, and
H Frenzel
September 1991,
The Journal of rheumatology,
R Rau, and
T Karger, and
G Herborn, and
H Frenzel
January 2015,
International journal of clinical and experimental pathology,
