-transparent.png){kind=logo}
Liver biopsy findings in patients with juvenile rheumatoid arthritis receiving long-term, weekly methotrexate therapy. 1996
Division of Pediatric Gastroenterology and Nutrition, Rainbow Babies and Childrens Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.
We performed percutaneous liver biopsy in nine children who had received a weekly dose of methotrexate, 10 mg/m2 per week, for at least 3 years to address the concern about subclinical liver toxicity from single, weekly, low-dose methotrexate therapy for juvenile rheumatoid arthritis. No patient had clinical or biochemical evidence of liver injury. All biopsy results were interpreted as normal. These results suggest that the recommendations of the American College of Rheumatology for adults receiving single weekly methotrexate therapy for rheumatoid arthritis can be extended to children.
Related Publications
S Kugathasan, and
A J Newman, and
B B Dahms, and
J T Boyle
January 2002,
Scandinavian journal of rheumatology,
S Kugathasan, and
A J Newman, and
B B Dahms, and
J T Boyle
February 1989,
Arthritis and rheumatism,
S Kugathasan, and
A J Newman, and
B B Dahms, and
J T Boyle
December 1997,
Arthritis and rheumatism,
S Kugathasan, and
A J Newman, and
B B Dahms, and
J T Boyle
March 1992,
The Journal of pediatrics,
S Kugathasan, and
A J Newman, and
B B Dahms, and
J T Boyle
January 1992,
Rheumatology international,
S Kugathasan, and
A J Newman, and
B B Dahms, and
J T Boyle
December 1987,
Arthritis and rheumatism,
S Kugathasan, and
A J Newman, and
B B Dahms, and
J T Boyle
April 1989,
The Journal of rheumatology,
S Kugathasan, and
A J Newman, and
B B Dahms, and
J T Boyle
December 1988,
Arthritis and rheumatism,
S Kugathasan, and
A J Newman, and
B B Dahms, and
J T Boyle
February 2010,
Arthritis and rheumatism,
S Kugathasan, and
A J Newman, and
B B Dahms, and
J T Boyle
April 1991,
The Journal of pediatrics,
