Biomaterial Database

Herbal medicine in the treatment of Alzheimer's disease. 2015

Jian-guo Wu, and Yan-yan Wang, and Zi-lv Zhang, and Bin Yu

Tianjin University of Traditional Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, 300193, China.

Associated with the aging of our world population is a sharp increase in the incidence of Alzheimer's disease, which not only poses a significant health issue but also presents a serious social problem. Although pharmacological treatments were developed based on existing hypotheses, the disease pathogenesis remains to be fully elucidated. Given the complexity of Alzheimer's disease, Chinese herbal medicine appears to have therapeutic potential for Alzheimer's disease through multi-target and multi-pathway approach at cellular and molecular levels and holistic adjustment of the body at organ system levels. Recently, a significant breakthrough has been made in the research of Chinese medicine for Alzheimer's disease. In this article, we review the experimental research progress in understanding how Chinese medicine could be used for the treatment of Alzheimer's disease.

UI	MeSH Term	Description	Entries
D004365	Drugs, Chinese Herbal	Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.	Chinese Herbal Drugs,Plant Extracts, Chinese,Chinese Drugs, Plant,Chinese Plant Extracts,Extracts, Chinese Plant,Herbal Drugs, Chinese
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000544	Alzheimer Disease	A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	Acute Confusional Senile Dementia,Alzheimer's Diseases,Dementia, Alzheimer Type,Dementia, Senile,Presenile Alzheimer Dementia,Senile Dementia, Alzheimer Type,Alzheimer Dementia,Alzheimer Disease, Early Onset,Alzheimer Disease, Late Onset,Alzheimer Sclerosis,Alzheimer Syndrome,Alzheimer Type Senile Dementia,Alzheimer's Disease,Alzheimer's Disease, Focal Onset,Alzheimer-Type Dementia (ATD),Dementia, Presenile,Dementia, Primary Senile Degenerative,Early Onset Alzheimer Disease,Familial Alzheimer Disease (FAD),Focal Onset Alzheimer's Disease,Late Onset Alzheimer Disease,Primary Senile Degenerative Dementia,Senile Dementia, Acute Confusional,Alzheimer Dementias,Alzheimer Disease, Familial (FAD),Alzheimer Diseases,Alzheimer Type Dementia,Alzheimer Type Dementia (ATD),Alzheimers Diseases,Dementia, Alzheimer,Dementia, Alzheimer-Type (ATD),Familial Alzheimer Diseases (FAD),Presenile Dementia,Sclerosis, Alzheimer,Senile Dementia
D064209	Phytochemicals	A broad range of biologically active compounds which occur naturally in plants having important medicinal and nutritional properties.	Dietary Phytochemical,Plant Bioactive Compound,Plant Biologically Active Compound,Plant-Derived Chemical,Plant-Derived Compound,Bioactive Coumpounds, Plant,Biologically Active Coumpounds, Plant,Dietary Phytochemicals,Phytochemical,Phytonutrient,Phytonutrients,Plant Bioactive Compounds,Plant Biologically Active Compounds,Plant-Derived Chemicals,Plant-Derived Compounds,Bioactive Compound, Plant,Bioactive Compounds, Plant,Chemical, Plant-Derived,Chemicals, Plant-Derived,Compound, Plant Bioactive,Compound, Plant-Derived,Compounds, Plant Bioactive,Compounds, Plant-Derived,Coumpounds, Plant Bioactive,Phytochemical, Dietary,Phytochemicals, Dietary,Plant Bioactive Coumpounds,Plant Derived Chemical,Plant Derived Chemicals,Plant Derived Compound,Plant Derived Compounds