Biomaterial Database

Stopped-flow determination of procaine hydrochloride in pharmaceutical preparations. 1989

M C Gutiérrez, and A Gómez-Hens, and D Pérez-Bendito

Department of Analytical Chemistry, Faculty of Sciences, University of Córdoba, Spain.

A stopped-flow photometric method for the quantitative determination of procaine hydrochloride is proposed. It is based on the measurement of the rate of formation of a coloured product between procaine and sodium 1,2-naphthoquinone-4-sulphonate. The conversion of an equilibrium method to a kinetic method by the stopped-flow technique results in an improved detection limit and linear range, and in considerably increased sample throughput. A simple modular stopped-flow system has been used for this purpose. The results obtained on application of this method to the determination of procaine in various pharmaceutical preparations, show the suitability of the stopped-flow technique for routine pharmaceutical analyses.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D011343	Procaine	A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).	Anuject,Geriocaine,Gerokit,Hewedolor-Procain,Lophakomp-Procain N,Novocain,Novocaine,Procain Braun,Procain Jenapharm,Procain Rödler,Procain Steigerwald,Procain curasan,Procaina Serra,Procaine Hydrochloride,Pröcaine chlorhydrate Lavoisier,Röwo Procain,procain-loges,Hydrochloride, Procaine
D002138	Calibration	Determination, by measurement or comparison with a standard, of the correct value of each scale reading on a meter or other measuring instrument; or determination of the settings of a control device that correspond to particular values of voltage, current, frequency or other output.	Calibrations
D004304	Dosage Forms	Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.	Dosage Form,Form, Dosage,Forms, Dosage
D013053	Spectrophotometry	The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.