BIOMAT Database Logo BIOMAT Database Logo

[In vitro activity of clofazimine alone and in combination with amikacin, roxithromycin, rifampicin and rifapentine against Mycobacterium avium-intracellulare]. 1989

M Casal Román, and F Rodríguez López, and R Villalba Montoro, and A I González Requero

The activity of clofazimine, amikacin, roxithromycin, rifampicin and rifapentine was tested, alone and in association, against Mycobacterium avium intracellulare. Clofazimine, amikacin and rifapentine were shown to be very active. With all established associations, the MIC observed for each drug alone was appreciably reduced.

UI MeSH Term Description Entries
D002991 Clofazimine A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619) B-663,G-30,320,Lamprene,N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-((1-methylethyl)imino)-2-phenazinamine,B 663,B663,G 30,320,G30,320
D004347 Drug Interactions The action of a drug that may affect the activity, metabolism, or toxicity of another drug. Drug Interaction,Interaction, Drug,Interactions, Drug
D004352 Drug Resistance, Microbial The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS). Antibiotic Resistance,Antibiotic Resistance, Microbial,Antimicrobial Resistance, Drug,Antimicrobial Drug Resistance,Antimicrobial Drug Resistances,Antimicrobial Resistances, Drug,Drug Antimicrobial Resistance,Drug Antimicrobial Resistances,Drug Resistances, Microbial,Resistance, Antibiotic,Resistance, Drug Antimicrobial,Resistances, Drug Antimicrobial
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D000583 Amikacin A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics. A.M.K,Amikacin Sulfate,Amikacina Medical,Amikacina Normon,Amikafur,Amikalem,Amikason's,Amikayect,Amikin,Amiklin,Amukin,BB-K 8,BB-K8,Biclin,Biklin,Gamikal,Kanbine,Oprad,Yectamid,BB K 8,BB K8,BBK 8,BBK8,Medical, Amikacina,Normon, Amikacina,Sulfate, Amikacin
D012293 Rifampin A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160) Rifampicin,Benemycin,Rifadin,Rimactan,Rimactane,Tubocin
D015269 Mycobacterium avium Complex A complex that includes several strains of M. avium. M. intracellulare is not easily distinguished from M. avium and therefore is included in the complex. These organisms are most frequently found in pulmonary secretions from persons with a tuberculous-like mycobacteriosis. Strains of this complex have also been associated with childhood lymphadenitis and AIDS; M. avium alone causes tuberculosis in a variety of birds and other animals, including pigs. Battey Bacillus,MAIC,Mycobacterium avium-intracellulare,Mycobacterium avium-intracellulare Complex,Mycobacterium intracellulare,Nocardia intracellularis
D015575 Roxithromycin Semisynthetic derivative of erythromycin. It is concentrated by human phagocytes and is bioactive intracellularly. While the drug is active against a wide spectrum of pathogens, it is particularly effective in the treatment of respiratory and genital tract infections. Biaxsig,Claramid,Infectoroxit,MTW-Roxithromycin,Macrosil,RU 28965,RU 965,RU-28965,RU-965,Rotesan,Rotramin,Roxi 1A Pharma,Roxi Basics,Roxi TAD,Roxi-Puren,Roxi-Q,Roxi-Wolff,Roxi-paed 1A Pharma,Roxi-saar,Roxibeta,Roxigamma,Roxigrün,Roxihexal,Roxithro-Lich,Rulid,Rulide,roxi von ct,roxidura,RU28965,RU965

Related Publications

M Casal Román, and F Rodríguez López, and R Villalba Montoro, and A I González Requero
Activities of roxithromycin used alone and in combination with ethambutol, rifampin, amikacin, ofloxacin, and clofazimine against Mycobacterium avium complex.
June 1994, Antimicrobial agents and chemotherapy,
M Casal Román, and F Rodríguez López, and R Villalba Montoro, and A I González Requero
Spectrum of activity of levofloxacin against nontuberculous mycobacteria and its activity against the Mycobacterium avium complex in combination with ethambutol, rifampin, roxithromycin, amikacin, and clofazimine.
November 1996, Antimicrobial agents and chemotherapy,
M Casal Román, and F Rodríguez López, and R Villalba Montoro, and A I González Requero
[Activity of azithromycin and roxithromycin alone or in combination against Mycobacterium avium and Mycobacterium xenopi].
May 1990, Pathologie-biologie,
M Casal Román, and F Rodríguez López, and R Villalba Montoro, and A I González Requero
Activities of amikacin, roxithromycin, and azithromycin alone or in combination with tumor necrosis factor against Mycobacterium avium complex.
August 1988, Antimicrobial agents and chemotherapy,
M Casal Román, and F Rodríguez López, and R Villalba Montoro, and A I González Requero
Postantibiotic effect of amikacin and rifapentine against Mycobacterium avium complex.
October 1992, The Journal of infectious diseases,
M Casal Román, and F Rodríguez López, and R Villalba Montoro, and A I González Requero
Activity of rifabutin alone and in combination with clofazimine, kanamycin and ethambutol against Mycobacterium intracellulare infections in mice.
September 1989, Tubercle,
M Casal Román, and F Rodríguez López, and R Villalba Montoro, and A I González Requero
In vitro activity of amikacin against Mycobacterium avium.
February 1990, Antimicrobial agents and chemotherapy,
M Casal Román, and F Rodríguez López, and R Villalba Montoro, and A I González Requero
[Bacteriostatic and bactericidal study of rifabutine and clofazimine in combination against Mycobacterium avium-intracellulare and Mycobacterium xenopi].
June 1989, Pathologie-biologie,
M Casal Román, and F Rodríguez López, and R Villalba Montoro, and A I González Requero
[Mycobacterium avium intracellulare infections. Treatment with a clarithromycin-clofazimine combination. 18 cases].
December 1993, Presse medicale (Paris, France : 1983),
M Casal Román, and F Rodríguez López, and R Villalba Montoro, and A I González Requero
Lack of activities of amikacin and sulphamethoxazole against Mycobacterium avium-intracellulare.
January 1993, International journal of clinical pharmacology research,
Copied contents to your clipboard!