BIOMAT Database Logo BIOMAT Database Logo

Reverse transcriptase inhibitors drug resistance mutations in drug-naive HIV type 1 positive Kenyans. 2011

A K Nyamache, and R Waihenya, and Z W Ng'ang'a, and A W Muigai, and S A Khamadi

OBJECTIVE To evaluate the extent of HIV-1 drug resistance among drug naive Kenyan individuals. METHODS Cross-sectional study. METHODS Kenya Medical Research Institute HIV laboratory Nairobi, Kenya. METHODS A total of seventy eight HIV-1 positive drug naive subjects randomised from five Kenyan provincial hospitals between April and June 2004. RESULTS A major non-nucleoside reverse transcriptase (NNRTI) an associated mutation was found in one patient (1.3%). NNRTI associated resistance mutations were present at amino acid codon sites G98A (2.56%); K103E (1.3%) and L100F (3.57%) prevalences. Baseline resistance may compromise the response to standard NNRTI-based first-line ART in 1.3 % of the study subjects. CONCLUSIONS This indicates in general, that drug resistance among HIV-1 positive drug naive individual is at low thresholds (1.3%) but the problem could be more serious than reported here. Continuous resistance monitoring is therefore warranted to maintain individual and population-level ART effectiveness.

UI MeSH Term Description Entries
D007630 Kenya A republic in eastern Africa, south of ETHIOPIA, west of SOMALIA with TANZANIA to its south, and coastline on the Indian Ocean. Its capital is Nairobi. Republic of Kenya
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D003062 Codon A set of three nucleotides in a protein coding sequence that specifies individual amino acids or a termination signal (CODON, TERMINATOR). Most codons are universal, but some organisms do not produce the transfer RNAs (RNA, TRANSFER) complementary to all codons. These codons are referred to as unassigned codons (CODONS, NONSENSE). Codon, Sense,Sense Codon,Codons,Codons, Sense,Sense Codons
D005260 Female Females
D006679 HIV Seropositivity Development of neutralizing antibodies in individuals who have been exposed to the human immunodeficiency virus (HIV/HTLV-III/LAV). AIDS Seroconversion,AIDS Seropositivity,Anti-HIV Positivity,HIV Antibody Positivity,HIV Seroconversion,HTLV-III Seroconversion,HTLV-III Seropositivity,AIDS Seroconversions,AIDS Seropositivities,Anti HIV Positivity,Anti-HIV Positivities,Antibody Positivities, HIV,Antibody Positivity, HIV,HIV Antibody Positivities,HIV Seroconversions,HIV Seropositivities,HTLV III Seroconversion,HTLV III Seropositivity,HTLV-III Seroconversions,HTLV-III Seropositivities,Positivities, Anti-HIV,Positivities, HIV Antibody,Positivity, Anti-HIV,Positivity, HIV Antibody,Seroconversion, AIDS,Seroconversion, HIV,Seroconversion, HTLV-III,Seroconversions, AIDS,Seroconversions, HIV,Seroconversions, HTLV-III,Seropositivities, AIDS,Seropositivities, HIV,Seropositivities, HTLV-III,Seropositivity, AIDS,Seropositivity, HIV,Seropositivity, HTLV-III
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

A K Nyamache, and R Waihenya, and Z W Ng'ang'a, and A W Muigai, and S A Khamadi
Identification of reverse transcriptase mutations associated with HIV-1 drug resistance mainly against non-nucleoside reverse transcriptase inhibitors in treatment-naive patients.
July 1999, AIDS (London, England),
A K Nyamache, and R Waihenya, and Z W Ng'ang'a, and A W Muigai, and S A Khamadi
Detection of low-frequency HIV type 1 reverse transcriptase drug resistance mutations by ultradeep sequencing in naive HIV type 1-infected individuals.
February 2014, AIDS research and human retroviruses,
A K Nyamache, and R Waihenya, and Z W Ng'ang'a, and A W Muigai, and S A Khamadi
Identification of insertion mutations in HIV-1 reverse transcriptase causing multiple drug resistance to nucleoside analogue reverse transcriptase inhibitors.
January 1999, Journal of human virology,
A K Nyamache, and R Waihenya, and Z W Ng'ang'a, and A W Muigai, and S A Khamadi
Mutations conferring drug resistance affect eukaryotic expression of HIV type 1 reverse transcriptase.
February 2004, AIDS research and human retroviruses,
A K Nyamache, and R Waihenya, and Z W Ng'ang'a, and A W Muigai, and S A Khamadi
Short communication: Drug resistance mutations in the HIV type 1 protease and reverse transcriptase genes in antiretroviral-naive Vietnamese children.
October 2012, AIDS research and human retroviruses,
A K Nyamache, and R Waihenya, and Z W Ng'ang'a, and A W Muigai, and S A Khamadi
Update on primary HIV-1 resistance in Argentina: emergence of mutations conferring high-level resistance to nonnucleoside reverse transcriptase inhibitors in drug-naive patients.
August 2006, Journal of acquired immune deficiency syndromes (1999),
A K Nyamache, and R Waihenya, and Z W Ng'ang'a, and A W Muigai, and S A Khamadi
HIV-1 protease and reverse transcriptase mutations for drug resistance surveillance.
January 2007, AIDS (London, England),
A K Nyamache, and R Waihenya, and Z W Ng'ang'a, and A W Muigai, and S A Khamadi
Fast genotypic detection of drug resistance mutations in the HIV-1 reverse transcriptase gene of treatment-naive patients.
January 1998, Journal of human virology,
A K Nyamache, and R Waihenya, and Z W Ng'ang'a, and A W Muigai, and S A Khamadi
Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase.
December 2020, Nature communications,
A K Nyamache, and R Waihenya, and Z W Ng'ang'a, and A W Muigai, and S A Khamadi
Phylogenetic analysis of reverse transcriptase in antiretroviral drug-naive Korean HIV type 1 patients.
November 2001, AIDS research and human retroviruses,
Copied contents to your clipboard!