[Biclonal gammopathy in a patient with immunoblastic lymphadenopathy like T cell lymphoma]. 1989

M Murakami, and K Sugiura

A case of immunoblastic lymphadenopathy like T cell lymphoma (IBL like T cell lymphoma) associated with biclonal gammopathy is reported. The patient is a 79 year-old male who was admitted to our hospital for generalized lymphadenopathy in January 1987. The lymph node biopsy revealed complete architectural effacement with replacement by a diffuse cellular infiltrate of immunoblasts and pale cells which have a T cell phenotype. A diagnosis of IBL like T cell lymphoma was made. Of interest, high serum level of IgG (6,630 mg/dl) was noted, and immunoelectrophoresis revealed biclonal gammopathy (IgG kappa, IgG lambda), but no remarkable abnormalities were found in the bone marrow aspiration and bone survey. We treated the patient with two courses of CHOP therapy, which resulted in marked improvement of generalized lymphadenopathy and disappearance of biclonal gammopathy. However, relapse was noted a month later without reappearance of biclonal gammopathy. The rebiopsy of lymph node revealed a new appearance of Lennert's lesions and decrease of immunoblasts in number. The patient received two courses of M-BACOD therapy, which achieved complete remission, and the patient remained in remission for more than 17 months.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007119 Immunoblastic Lymphadenopathy A disorder characterized by proliferation of arborizing small vessels, prominent immunoblastic proliferations and amorphous acidophilic interstitial material. Clinical manifestations include fever, sweats, weight loss, generalized lymphadenopathy and frequently hepatosplenomegaly. Angioimmunoblastic Lymphadenopathy,Lymphadenopathy, Immunoblastic,Angioimmunoblastic Lymphadenopathies,Immunoblastic Lymphadenopathies,Lymphadenopathies, Angioimmunoblastic,Lymphadenopathies, Immunoblastic,Lymphadenopathy, Angioimmunoblastic
D007145 Immunoglobulin kappa-Chains One of the types of light chains of the immunoglobulins with a molecular weight of approximately 22 kDa. Ig kappa Chains,Immunoglobulins, kappa-Chain,kappa-Immunoglobulin Light Chains,Immunoglobulin kappa-Chain,kappa-Chain Immunoglobulins,kappa-Immunoglobulin Light Chain,kappa-Immunoglobulin Subgroup VK-12,kappa-Immunoglobulin Subgroup VK-21,Chains, Ig kappa,Immunoglobulin kappa Chain,Immunoglobulin kappa Chains,Immunoglobulins, kappa Chain,Light Chain, kappa-Immunoglobulin,Light Chains, kappa-Immunoglobulin,kappa Chain Immunoglobulins,kappa Chains, Ig,kappa Immunoglobulin Light Chain,kappa Immunoglobulin Light Chains,kappa Immunoglobulin Subgroup VK 12,kappa Immunoglobulin Subgroup VK 21,kappa-Chain, Immunoglobulin,kappa-Chains, Immunoglobulin
D007146 Immunoglobulin lambda-Chains One of the types of light chain subunits of the immunoglobulins with a molecular weight of approximately 22 kDa. Ig lambda Chains,Immunoglobulins, lambda-Chain,Immunoglobulin lambda-Chain,lambda-1-Immunoglobulin,lambda-2-Immunoglobulin,lambda-Chain Immunoglobulins,lambda-Immunoglobulin Light Chain,lambda-Immunoglobulin Light Chains,lambda-x Immunoglobulin,Chains, Ig lambda,Chains, lambda-Immunoglobulin Light,Immunoglobulin lambda Chain,Immunoglobulin lambda Chains,Immunoglobulin, lambda-x,Immunoglobulins, lambda Chain,Light Chain, lambda-Immunoglobulin,Light Chains, lambda-Immunoglobulin,lambda 1 Immunoglobulin,lambda 2 Immunoglobulin,lambda Chain Immunoglobulins,lambda Chains, Ig,lambda Immunoglobulin Light Chain,lambda Immunoglobulin Light Chains,lambda x Immunoglobulin,lambda-Chain, Immunoglobulin,lambda-Chains, Immunoglobulin
D008223 Lymphoma A general term for various neoplastic diseases of the lymphoid tissue. Germinoblastoma,Lymphoma, Malignant,Reticulolymphosarcoma,Sarcoma, Germinoblastic,Germinoblastic Sarcoma,Germinoblastic Sarcomas,Germinoblastomas,Lymphomas,Lymphomas, Malignant,Malignant Lymphoma,Malignant Lymphomas,Reticulolymphosarcomas,Sarcomas, Germinoblastic
D008297 Male Males
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006942 Hypergammaglobulinemia An excess of GAMMA-GLOBULINS in the serum due to chronic infections or PARAPROTEINEMIAS. Hyperimmunoglobulinemia,Hypergammaglobulinemias,Hyperimmunoglobulinemias
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D001706 Biopsy Removal and pathologic examination of specimens from the living body. Biopsies

Related Publications

M Murakami, and K Sugiura
January 1994, [Rinsho ketsueki] The Japanese journal of clinical hematology,
M Murakami, and K Sugiura
June 1991, Acta paediatrica Japonica : Overseas edition,
M Murakami, and K Sugiura
January 1982, Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
M Murakami, and K Sugiura
August 1996, [Rinsho ketsueki] The Japanese journal of clinical hematology,
M Murakami, and K Sugiura
November 1983, [Rinsho ketsueki] The Japanese journal of clinical hematology,
Copied contents to your clipboard!