Biomaterial Database

Toxic effects of mercurials on thyroid function of the catfish, Clarias batrachus (L.). 1989

R Kirubagaran, and K P Joy

Centre of Advanced Study in Zoology, Banaras Hindu University, Varanasi, India.

The toxic effects of mercurials on the thyroid activity of Clarias batrachus were evaluated after exposure for 45, 90, and 180 days during gonadal recrudescence. Histologically, the thyroid follicles were active with hypertrophied epithelium and reduced colloid content in 90- and 180-day mercuric chloride (HgCl2)- and 90-day methylmercuric chloride (CH3HgCl)-treated fish. In 180-day CH3HgCl and 90- and 180-day emisan 6 groups, the follicular epithelium appeared atrophic with a wavy and irregular outline and with hypertrophied and hyperplastic cells present in some parts of the epithelium. Thyroidal 131I uptake was inhibited in all groups and at all durations. Protein-bound iodine (PBI) levels decreased significantly in the 45-day CH3HgCl group and in all the mercurial groups treated for 90 and 180 days. Of the three mercurials, CH3HgCl was found to be more toxic than the other two in inhibiting thyroidal 131I uptake and PBI level at all durations.

UI	MeSH Term	Description	Entries
D008627	Mercuric Chloride	Mercury chloride (HgCl2). A highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant.	Mercury Dichloride,Corrosive Sublimate,HgCl2,Mercuric Perchloride,Mercury Bichloride,Mercury Perchloride,Sublimate,Bichloride, Mercury,Chloride, Mercuric,Dichloride, Mercury,Perchloride, Mercuric,Perchloride, Mercury,Sublimate, Corrosive
D008767	Methylmercury Compounds	Organic compounds in which mercury is attached to a methyl group.	Methyl Mercury Compounds,Compounds, Methyl Mercury,Compounds, Methylmercury,Mercury Compounds, Methyl
D002397	Catfishes	Common name of the order Siluriformes. This order contains many families and over 2,000 species, including venomous species. Heteropneustes and Plotosus genera have dangerous stings and are aggressive. Most species are passive stingers.	Eremophilus mutisii,Heteropneustes,Plotosus,Siluriformes,Arius,Catfish,Colombian Catfish,Catfish, Colombian
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013960	Thyroid Function Tests	Blood tests used to evaluate the functioning of the thyroid gland.	Jostel's TSH Index,Jostel's Thyrotropin Index,Protein-Bound Iodine Test,SPINA-GD,SPINA-GT,Secretory Capacity of the Thyroid Gland,Sum Activity of Peripheral Deiodinases,Thyrotroph Thyroid Hormone Sensitivity Index,Thyroid Gland Function Tests,Function Test, Thyroid,Iodine Test, Protein-Bound,Jostel TSH Index,Jostel Thyrotropin Index,Jostel's TSH Indices,Jostels TSH Index,Jostels Thyrotropin Index,Protein Bound Iodine Test,Protein-Bound Iodine Tests,TSH Index, Jostel's,Test, Protein-Bound Iodine,Test, Thyroid Function,Thyroid Function Test,Thyrotropin Index, Jostel's
D013961	Thyroid Gland	A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.	Thyroid,Gland, Thyroid,Glands, Thyroid,Thyroid Glands,Thyroids
D013975	Thyroxine-Binding Proteins	Blood proteins that bind to THYROID HORMONES such as THYROXINE and transport them throughout the circulatory system.	Thyroxine Transport Protein,Thyroxine-Binding Protein,Thyroxine Binding Protein,Thyroxine Binding Proteins